Andrew Bateman, PhD
growth factors • wounds • cancer • neuroprotection
My research focuses on how cells communicate. I am currently studying a protein called progranulin, which is secreted by cells and instructs nearby cells to divide and to move. It also inhibits cell death caused by challenges such as starvation or chemotherapeutic drugs. There are many important roles for this molecule. It is over expressed in many cancers and renders cancer cells much more aggressive. Blocking progranulin may be a route to cancer therapy. In the brain progranulin keeps nerve cells alive. Losing only one half of the brain's progranulin levels by mutation causes a devastating brain disease called frontotemporal dementia (FTD). I wish to understand how progranulin protects the brain. Progranulin reduces inflammation. Its levels increase rapidly in injured tissues. We have shown that progranulin helps the wound repair process. This may help diabetics with chronic ulcers that often heal badly. Progranulin also helps regenerate new blood vessels (angiogenesis).
Palfree RGE, Bennett HPJ, Bateman A (2015) The Evolution of the Secreted Regulatory Protein Progranulin. PLoS ONE 10(8): e0133749. doi:10.1371/journal.pone.0133749.
Tauffenberger A, Chitramuthu BP, Bateman A, Bennett HP, Parker JA.(2013) Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models Hum Mol Genet. 2013 Feb 15;22(4):782-94. PMID: 23172908.
Toh H, Cao M, Daniels E., Bateman A Expression of the growth factor progranulin in endothelial cells influences growth and development of blood vessels: a novel mouse model. PLoS ONE 8(5): e64989. PMID: 23741441.
Songsrirote K, Li Z, Ashford D, Bateman A, Thomas-Oates J. Development and Application of Mass Spectrometric Methods for the Analysis of Progranulin N-Glycosylation J Proteomics. 2010 Jun 16;73(8):1479-90. PMID: 20188224.
Ryan CL, Baranowski DC, Chitramuthu BP, Malik S, Li Z, Cao M, Minotti S, Durham HD, Kay DG, Shaw CA, Bennett HPJ and Bateman A. Progranulin is expressed within motor neurons and promotes neuronal cell survival. BMC Struct Biol. 2009;9:75. PMID: 20017931.