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angle-left Asangla Ao, PhD

Associate Investigator, RI-MUHC, Royal Victoria Hospital

Child Health and Human Development Program

Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, McGill University

 

Keywords


aneuploidy • chromosome mosaicism • chromosome translocation • preimplantation genetic diagnosis • fertility

Research Focus


My research focuses on the basic understanding of early human embryo development. The research is focused on to investigate the incidence and mechanisms involved in chromosome abnormality in early embryos. The knowledge we gain by these studies not only helps our basic understanding of early human embryo development but we have been able to use some aspects of our research findings for clinical application.

Selected Publications


Click on Pubmed to see my current publications list

  • Yilmaz A, Zhang L, Zhang XY, Son WY, Holzer H, Ao A. Chromosomal complement and clinical relevance of multinucleated embryos in PGD and PGS cycles. Reprod Biomed Online. 2014 Mar;28(3):380-7. doi: 10.1016/j.rbmo.2013.11.003. Epub 2013 Nov 22. PubMed PMID: 24447961.

  • Yilmaz A, Zhang XY, Chung JT, Tan SL, Holzer H, Ao A. Chromosome segregation analysis in human embryos obtained from couples involving male carriers of reciprocal or Robertsonian translocation. PLoS One. 2012;7(9):e46046. doi: 10.1371/journal.pone.0046046. Epub 2012 Sep 27. PubMed PMID: 23029381; PubMed Central PMCID: PMC3459837.

  • Zhang L, Yilmaz A, Chian RC, Son WY, Zhang XY, Kong D, Dahan M, Holzer H, Tan SL, Ao A. Reliable preimplantation genetic diagnosis in thawed human embryos vitrified at cleavage stages without biopsy. J Assist Reprod Genet. 2011 Jul;28(7):597-602. doi: 10.1007/s10815-011-9556-2. Epub 2011 Mar 25. PubMed PMID: 21437672; PubMed Central PMCID: PMC3162057.

  • Ao A, Zhang XY, Tan SL. First successful pregnancy following PGD for chromosome translocation on embryos generated from in-vitro matured oocytes: a case report.Reprod Biomed Online. 2011 Apr;22(4):371-5. doi: 10.1016/j.rbmo.2010.11.014. Epub 2010 Nov 25. PubMed PMID: 21324743.

  • Zhang XY, Ata B, Son WY, Buckett WM, Tan SL, Ao A. Chromosome abnormality rates in human embryos obtained from in-vitro maturation and IVF treatment cycles. Reprod Biomed Online. 2010 Oct;21(4):552-9. doi: 10.1016/j.rbmo.2010.05.002. Epub 2010 May 13. PubMed PMID: 20800547.