Bruce Mazer, MD
Asthma • food allergy • immune therapies • intravenous immunoglobulin • B-lymphocytes and mucosal responses • antigen presentation • IgE • IVIg • semaphorins
My research focuses on a combination of human studies and animal modeling to determine new ways of changing the immune response to allergens, and to help to naturally shape immune tolerance in individuals with allergies and asthma. Asthma and food allergies affect almost 20% of children in North America. These diseases are important causes of morbidity and mortality, and have a huge economic and social impact.
Desjardins M, Beland M, Lejtenyi D, Drolet JP, Lemire M, Tsoukas C, Ben-Shoshan M, Noya FJD, Alizadehfar R, McCusker CT, Mazer BD. Synergy Between the Interleukin-4 and Interleukin-21 Pathways Distinguishes Patients With Common Variable Immunodeficiency (CVID) at High Risk of Complications. Submitted JACI April 2015.
Massoud AH, Kaufman GN, Beland M, Mourad W, Piccirillo CA, Mazer BD. Peripherally Induced Foxp3+ Regulatory T Cells Mediate the Immunomodulatory Effects of Intravenous Immunoglobulin in Allergic Airways Disease. Submitted Mucosal Immunology June 2015.
Gabriel N Kaufman, Amir H Massoud, Madelaine Yona, Ciriaco A Piccirillo, Bruce D Mazer. (2015). Induction of regulatory T cells by IVIg: a bridge between adaptive and innate immunity. Frontiers in Immunology. 11(6): 469-475.
*Xue, D, *Kaufman GN, Beland M, *Massoud AH, Mindt BC, *Fiter R, Fixman ED, Martin JG, Friedel RH, Divangahi M, Fritz JH, Mazer BD. Semaphorin 4C protects against allergic inflammation by inducing Plasma-B10 and suppressing eosinophilia. Submitted Mucosal Immunolgy August 2015.