Errol Marliss, MD, FRCPC
protein metabolism • glucose turnover • insulin resistance • insulin and nutrient signaling • whole-body and tissue fuel homeostasis
My research focuses on nutrition and metabolism in obesity and diabetes. Our collaborative PI group has included Stéphanie Chevalier, José Morais, Terry Combs, and Réjeanne Gougeon. We firmly established that insulin resistance of protein metabolism accompanies those of glucose and lipids in many human conditions, and adiponectin resistance occurs with type 1 diabetes. Our in vivo "metabolic phenotyping" studies use state-of-the-art isotopic tracer methods enabling measurements of production and utilization of both glucose and protein. These are combined with metabolic rate measurements and serum analyses of hormones and substrates (including amino acids) implicated in the control of these processes. Furthermore, in muscle biopsies from these studies, regulatory steps have been analyzed and have provided new insights into the causation of the abnormalities and their genetic control. Our results have formed the basis for optimizing diets, and led to updated guidelines for dietary protein intakes in diabetes.
Combs, TP, Snell-Bergeon, JK, Maahs, DM, Bergman, BC, Lamarche, M, Iberkleid, L, AbdelBaky, O, Scherer, PE, Marliss, EB. Adiponectin-SOGA dissociation in Type 1 diabetes. J Clin Endocrinol Metab, 100(8):E1065–E1073, 2015. PMID: 26052615.
Chevalier, S, Burgos, SA, Morais, JA, Gougeon, R, Bassil, M, Lamarche, M, Marliss EB. Protein and glucose metabolism response to hyperinsulinemia, hyperglycemia and hyperaminoacidemia in obese, glucose tolerant men. Obesity 23: 351-358, 2015. PMID: 25452199.
Adegoke, OAJ, Chevalier, S, Morais, JA, Gougeon R, Kimball, SR, Jefferson, LS, Wing, SS and Marliss EB. Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men. Am J Physiol Endocrinol Metab 296:E105-E113,2009. PMID: 18957614.
Bassil M, Burgos S, Marliss EB, Morais JA, Chevalier S, Gougeon R. Hyperaminoacidaemia at postprandial levels does not modulate glucose metabolism in type 2 diabetes mellitus. Diabetologia. 54:1810-8, 2011. PMID: 21437771.
Bassil M, Marliss EB, Morais JA, Pereira S, Chevalier S, Gougeon R. Postprandial hyperaminoacidaemia overcomes insulin resistance of protein anabolism in men with type 2 diabetes. Diabetologia 54:648-656, 2011. PMID: 21109998.