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Geoffrey Hendy, PhD

Research Institute of the McGill University Health Centre

Regular Member
Endocrinology, Diabetes, Nutrition and Kidney Diseases
Musculoskeletal Disorders


McGill University Health Centre (MUHC)

Medical Scientist


McGill University

Professor, Medicine
Associate Professor, Human Genetics
Associate Professor, Physiology


Research Interest


My research focuses on the molecular genetics of mineral metabolism disorders with a focus on functional analysis of inherited mutations in genes controlling blood calcium and skeletal homeostasis.

Research Foci


  • calcium homeostasis
  • molecular genetics
  • calcium-sensing receptor
  • menin
  • mouse models

Keywords


Calcium homeostasis, molecular diagnostics, endocrine, functional analysis

Selected Publications


Click on Pubmed to see my current publications list

  • Puzhko, S., Goodyer, C.G., Kerachian, M.A., Canaff, L., Misra, M., Jüppner, H., Bastepe, M., Hendy, G.N. Parathyroid hormone signaling via Gas is selectively inhibited by an NH2-terminally truncated Gas: implications for pseudohypoparathyroidism. J. Bone Miner. Res. 26:2473-2485, 2011.

  • Canaff, L., Vanbellinghen, J-F., Kanazawa, I., Kwak, H., Garfield, N., Vautour, L., Hendy, G.N. Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: restoration of expression and activity by CHIP siRNA. J. Clin. Endocrinol. Metab. 97:E282-E291, 2012.

  • Canaff, L., Vanbellinghen, J-F., Kaji, H., Goltzman, D., Hendy, G.N. Impaired transforming growth factor-beta (TGF-b) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with Multiple Endocrine Neoplasia type 1 (MEN1). J. Biol. Chem. 287:8584-8597, 2012.

  • Hendy, G.N., Canaff, L., Cole, D.E.C. The CASR gene: Alternative splicing and transcriptional control, and calcium-sensing receptor (CaSR) protein: Structure and ligand binding sites. Best Pract Res Clin Endocrinol Metab 27: 285-301, 2013

  • Hendy, G.N., Cole, D.E.C. Invited Editorial. Ruling in a suspect: the role of AP2S1 mutations in familial hypocalciuric hypercalcemia type 3. J. Clin. Endocrinol. Metab. In press. 2013.