Jonathan Spicer, BSc (Hon), MD, PhD, FRCS - Jonathan Spicer, BSc (Hon), MD, PhD, FRCS - Research Institute MUHC
cancer • metastasis • neutrophil • inflammation • surgery
My research focuses on the understanding of the underlying molecular mechanisms that are responsible for the Neutrophil Extracellular Trap (NET) / Circulating Tumor Cell (CTC) interactions. We were the first group to demonstrate that such interactions facilitate metastatic progression and we are now working on elucidating the how NETs promote metastatic outgrowth and via which molecular targets they function. The ultimate goal is to identify specific targets that can be used to prevent metastatic progression in a wide array of cancer patients.
Cools-Lartigue J, Spicer J, Najmeh S, Ferri L. Neutrophil extracellular traps in cancer progression. Cell Mol Life Sci. 2014 Nov;71(21):4179-94. PMID: 25070012.
Cools-Lartigue J, Spicer J, McDonald B, Gowing S, Chow S, Giannias B, Bourdeau F, Kubes P, Ferri L. Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Invest. 2013 Jul 1. [Epub ahaed of print]. PMID: 23863628.
Spicer JD, McDonald B, Cools-Lartigue JJ, Chow SC, Giannias B, Kubes P, Ferri LE. Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells. Cancer Res. 2012 Aug 15;72(16):3919-27. PMID: 22751466.
Hsu RY, Chan CH, Spicer JD, Rousseau MC, Giannias B, Rousseau S, Ferri LE. LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis. Cancer Res. 2011 Mar 1;71(5):1989-98. PMID: 21363926.
McDonald B, Spicer J, Giannais B, Fallavollita L, Brodt P, Ferri LE. Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms. Int J Cancer. 2009 Sep 15;125(6):1298-305. PMID: 19431213.