Jun-Li Liu, PhD
growth and development • transgenic mice • Cre/loxP system • insulin-like growth factor • Reg family proteins
My research focuses on exploring novel growth factors that can be used to expand or preserve the islet beta cells, which make the key hormone insulin, against onset of diabetes mellitus. Our current focus is on a family of proteins normally produced in the pancreas, some of which have been shown to be effective in rodent models of the disease.
S Chowdhury, X Wang, CB Srikant, M Fu, Q Li, YJ Gong, G Ning, JL Liu. IGF-I overexpression stimulates CCN5/WISP2 expression in pancreatic β-cells, which promotes cell proliferation and survival against streptozotocin. Endocrinology 2014; 155: 1629-1642. PMID: 24552398.
B Li, Y Lu, CB Srikant, ZH Gao, JL Liu. Intestinal adaptation and Reg gene expression caused by anti-diabetic duodenal-jejunal bypass surgery in Zucker fatty rats. Am J Physiol-GI Liver 2013; 304: G635-G645. PMID: 23370676.
C Luo, B Li, L Liu, HP Yin, M Wang, JL Liu. Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells. Mol Cell Endocrinol 2013; 365:187-96. PMID: 23147030.
X Xiong, X Wang, B Li, S Chowdhury, Y Lu, CB Srikant, G Ning, JL Liu. Pancreatic isletspecific overexpression of Reg3β protein induced the expression of pro-islet genes and protected mice against streptozotocin-induced diabetes mellitus. Am J Physiol-Endo Metab; 300: E669-680; 2011. PMID: 21245462.
B Li, X Wang, JL Liu. Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice. Am J Physiol-GI Liver 2010; 299: G413-421. PMID: 20489047.