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Kolja Eppert, PhD

Research Institute of the McGill University Health Centre

Regular Member
Cancer
Medical Genetics and Genomics


McGill University Health Centre (MUHC)

Medical scientist, Division of Pediatric Hematology-Oncology, Montreal Children's Hospital


McGill University

Assistant Professor, Department of Pediatrics, Faculty of Medicine, McGill University


Research Interest


My research focuses on the fundamental biology of acute myelogenous leukemia (AML) stem cells in pediatric and adult patients. My laboratory aims to spearhead the development of new therapeutics for childhood AML, a type of cancer in which approximately 55% of young patients still lose their battle to survive despite aggressive therapy. My research in adult leukemia has resulted in characterization of the tightly linked biology of normal and cancerous blood stem cells, and in the development of leukemia stem cell gene signatures that predict patient survival. I am now applying this unique expertise and approach to the study of pediatric leukemia.

Research Foci


  • human leukemia
  • hematopoiesis
  • hematopietic stem cells
  • leukemic stem cells
  • drug discovery
  • xenotransplant models

Keywords


Pediatric leukemia, acute myelogenous leukemia, AML, pediatric acute myelogenous leukemia, stem cells, cell sorting, xenotransplantation, gene expression profiling, biostatistics, bioinformatics

Selected Publications


Click on Pubmed to see my current publications list

  • Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, Maclean N, Spagnuolo PA, Sharmeen S, Gebbia M, Urbanus M, Eppert K, Dissanayake D, Li X, Datti A, Ohashi PS, Wrana J, Rogers I, Corey SJ, Eaves C, Minden MD, Wang JCY, Dick JE, Nislow C, Giaever G, and Schimmer AD. "Lysosomal disruption as a therapeutic strategy for acute myeloid leukemia." Journal of Clinical Investigation 123(1):315-328, 2013 Jan.

  • Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, ChenX, Wang J, Rusch M … Eppert K … Mullighan CG. "The genetic basis of early T-cell precursor acute lymphoblastic Leukaemia." Nature 481(7380):157-63, 2012 Jan.

  • McDermott SP, Eppert K, Notta F, Isaac M, Datti A, Al-Awar R, Wrana J, Minden MD, Dick JE. "A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside." Blood 119(5):1200-7, 2012 Feb.

  • Eppert K, Takenaka K, Lechman ER, Waldron L, Nilsson B, Metzeler KH, Poeppl A, Ling V, Beyene J, Canty AJ, Danska JS, Bohlander SK, Buske C, Minden MD, Golub TR, Jurisica I, Ebert BL, Dick JE."Stem cell gene expression programs influence clinical outcome in human leukemia." Nature Medicine 17(9):1086-1093, 2011 Sept.

  • Milyavsky M, Gan OI, Trottier M, Komosa M, Tabach O, Notta F, Lechman E, Hermans KG, Eppert K, Konovalova Z, Ornatsky O, Domany E, Meyn MS, Dick JE. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell 6;7(2):186-97, 2010 Aug.