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Lisbet Haglund, PhD

Scientist, RI-MUHC, Montreal General Hospital

Injury Repair Recovery Program

Associate Professor, Department of Surgery, Division of Orthopaedics, Faculty of Medicine, McGill University

 

Keywords


IVD degeneration • IVD regeneration • mechanobiology • pain • molecular markers of degeneration

Research Focus


My research focuses on characterization of molecular mechanisms leading to intervertebral disc degeneration and progression, and to develop molecular markers to follow disease state, progression or effect of treatment, and most importantly novel therapeutic interventions for degenerative and painful intervertebral disc degeneration.

Selected Publications


Click on Pubmed to see my current publications list

  • Acute mechanical injury of the human intervertebral disc: link to degeneration and pain. Alkhatib B, Rosenzweig DH, Krock E, Roughley PJ, Beckman L, Steffen T, Weber MH, Ouellet JA, Haglund L. Eur Cell Mater. 2014 Sep 12;28:98-110 PMID: 25214017.

  • Physiological loading can restore the proteoglycan content in a model of early IVD degeneration. Gawri R, Moir J, Ouellet J, Beckman L, Steffen T, Roughley P, Haglund L. PLoS One. 2014 Jul 3;9(7):e101233. doi: 10.1371/journal.pone.0101233. eCollection 2014. PMID: 24992586.

  • Painful, degenerating intervertebral discs up-regulate neurite sprouting and CGRP through nociceptive factors. Krock E, Rosenzweig DH, Chabot-Doré AJ, Jarzem P, Weber MH, Ouellet JA, Stone LS, Haglund L. J Cell Mol Med. 2014 Jun;18(6):1213-25. doi: 10.1111/jcmm.12268. Epub 2014 Mar 20. PMID: 24650225.

  • High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain. Gawri R, Rosenzweig DH, Krock E, Ouellet JA, Stone LS, Quinn TM, Haglund L. Arthritis Res Ther. 2014 Jan 23;16(1):R21. doi: 10.1186/ar4449. PMID: 24457003.

  • Chondroadherin fragmentation mediated by the protease HTRA1 distinguishes human intervertebral disc degeneration from normal aging. Akhatib B, Onnerfjord P, Gawri R, Ouellet J, Jarzem P, Heinegård D, Mort J, Roughley P, Haglund L. J Biol Chem. 2013 Jun 28;288(26):19280-7. doi: 10.1074/jbc.M112.443010. Epub 2013 May 14. PMID: 23673665.