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Livia Garzia, PhD

Junior Scientist, RI-MUHC, Glen site

Cancer Research Program

Assistant Professor, Department of Medicine, Division of Orthopaedic Surgery, Faculty of Medicine, McGill University

 

Keywords


Functional genomics • genetics • mouse models • pediatric cancers

Research Focus


My research aims to unravel the genetic bases of cancer recurrence and metastasis in pediatric cancers such as bone sarcomas and brain tumours. I am focused on understanding how gene function is altered during the process of metastasis initiation, maintenance and progression. Ultimately, I hope to contribute to finding efficacious ways to cure and prevent metastatic pediatric cancers.

Selected Publications


Click on Pubmed to see my current publications list

  • Cavalli FMG, Remke M, Rampasek L, Peacock J, Shih DJH, Luu B, Garzia L, (…) Intertumoral Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. 2017 Jun 12;31(6):737-754.e6. doi: 10.1016/j.ccell.2017.05.005. PMID: 28609654.

  • Holgado BL, Guerreiro Stucklin A, Garzia L, Daniels C, Taylor MD. Tailoring Medulloblastoma Treatment Through Genomics: Making a Change, One Subgroup at a Time. Annu Rev Genomics Hum Genet. 2017 Aug 31;18:143-166. doi: 10.1146/annurev-genom-091416-035434. Epub 2017 May 5. PMID: 28475368.

  • Morrissy AS, Garzia L,(…) Divergent clonal selection dominates medulloblastoma at recurrence. Nature. 2016 Jan 21;529(7586):351-7. doi:10.1038/nature16478. Epub 2016 Jan 13. PMID: 26760213.

  • Northcott PA, Shih DJ, Peacock J, Garzia L, (…) Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 2012 Aug 2;488(7409):49-56. doi: 10.1038/nature11327. PMID: 22832581.

  • Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, (…) Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature. 2012 Feb15;482(7386):529-33. doi: 10.1038/nature10825. PMID: 22343890.