Louise Larose, PhD
intracellular signaling • adaptor proteins • unfolded protein response • insulin resistance • obesity and diabetes
My research focuses on understanding molecular mechanisms involved in signal transduction regulating critical cellular functions such as embryonic development, proliferation, metabolism and response to stress. We particularly investigate the role of intracellular adaptor molecules that integrate signal transduction pathways by assembling molecular complexes involved in regulating hepatic insulin sensitivity and pancreatic β cell function. More recently, we developed a special interest for the role of the adaptor proteins Nck in molecular mechanisms regulating the unfolded protein response in normal physiological conditions and human pathogenesis associated with impaired glucose homeostasis, and insulin production and biological actions.
Hui, L., J. Dusseault and L. Larose. Nck1 depletion induced activation of the PI3K/Akt pathway by attenuating PTP1B protein expression. Cell Commun Signal. 14;12(1):71, 2014 PMID: 25398386.
Yamani, L., M., Latreille and L. Larose. Interaction of Nck1 and PERK phosphorylated at Y561 negatively modulates PERK activity and PERK regulation of pancreatic β cell proinsulin content. Mol Biol Cell, 25:702-11, 2014 Epub Dec 26, 2013. PMID: 24371088.
Latreille, M., Abu-Thuraia, A., Oliva, R., Zuo, D., and L. Larose. Casein Kinase Iγ2 Impairs Fibroblasts Actin Stress Fibers Formation and Delays Cell Cycle Progression in G1. Int. J. Cell Biol. Focus Issue on Cytoskeleton Proteins. Volume 2012 (2012) ID 684684, 15 pages. Epub 2012 March 7. PMID: 22496693.
Labelle-Côté, M., J. Dusseault, S. Ismaïl, A. Picard-Cloutier, P.M. Siegel and L. Larose. Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo BMC Cancer 11:443-462, 2011 Epub 2011 October 12. PMID: 21992144.
Latreille, M., M.-K. Laberge, G. Bourret, L. Yamani and L. Larose. Deletion of Nck1 attenuates hepatic ER stress signaling, improves glucose tolerance and insulin signaling in liver of obese mice. Am J Physiol Endocrinol Metab. 300(3):E423-34, 2011. PMID: 20587749.