Richard Kremer, MD, PhD, FRCPC - Richard Kremer, MD, PhD, FRCPC - Research Institute MUHC
vitamin D • PTHrP • osteoporosis • bone strength • animal models
My research focuses on trying to elucidate how 1, 25-dihydroxyvitamin D3 1, 25(OH) 2D3, the active form of vitamin D, influences cell growth and differentiation in the skeleton and in cancer cells. An extension of these studies is to elaborate new therapeutic strategies with vitamin D derivatives in osteoporosis and in cancer. For this purpose we developed animal models to study the efficacy of vitamin D and its analogs in models of osteoporosis and cancer. In collaboration with colleagues in Australia and in the US we discovered that a lack of vitamin D results in fat accumulation in bone and muscle with deleterious consequences for the musculoskeletal system. We also reported that a lack of vitamin D leads to accelerated development of breast cancer. Another major focus of our research activities has been to establish the role of parathyroid hormone related protein (PTHrP) in tumor initiation, growth and metastasis. This has led to the development of a novel targeted therapy against breast cancer using monoclonal antibodies raised against PTHrP.
Kremer R, Gagnon B, Meguerditchian AN, Nadeau L, Mayo N. Effects of oral bisphosphonates for osteoporosis on development of skeletal metastases in women with breast cancer: Results from a pharmaco-epidemiological study. J. Natl Cancer Inst. 106(11), 2014.
Huang DC, Yang XF, Camirand A, Kremer R. Suppression of parathyroid hormone-related peptide in a female mouse xenograft model identifies a novel therapeutic target against melanoma. Endocrinology 155(10):3739-49, 2014.
Li J, Karaplis AC, Huang DC, Siegel PM, Camirand A, Yang XF, Muller WJ, Kremer R. PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target J Clin Invest. 121(12):4655-69, 2011.
Gilsanz V, Kremer A, Mo AO, Wren TA, Kremer R. Vitamin D status and its relation to muscle mass and muscle fat in young women.J Clin Endocrinol Metab 95(4):1595-1601, 2010.
Gustavo Duque, Dao Chao Huang, Michael Macoritto, Daniel Rivas, Xian Fang Yang, Richard Kremer. Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis. Stem Cells 27(3):550-558, 2009.