Robert Sladek, MD
genetics • type 2 diabetes • obesity
My research focuses on learning how genetic mutations cause diabetes and other complex diseases. To do this, my group has developed new approaches to identify genetic changes across the whole human genome that are associated with type 2 diabetes, and also to identify the effects of genetic variation on RNA splicing and gene activation in mouse strains and human populations. Current projects in the lab center on developing new experimental techniques to learn how genetic changes within individual genes and proteins can impair cell metabolism and cause diabetes. Reflecting the increasing impact of diabetes and obesity on global health, much of the group's research in the genetics of diabetes takes place as part of research teams that involve scientists in America, Europe and Asia.
Berard DJ, Michaud F, Mahshid S, Ahamed MJ, McFaul CM, Leith JS, Bérubé P, Sladek R, Reisner W, Leslie SR. Convex lens-induced nanoscale templating. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13295-300. PMID: 25092333.
Cornes BK, Brody JA, Nikpoor N, et al. "Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014 Jun;7(3):374-82. PMID: 24951664.
Boivin GA, Pothlichet J, Skamene E, Brown EG, Loredo-Osti JC, Sladek R, Vidal SM. "Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68." Journal of Immunology. 2012 Apr 15; 188(8):3949-60. PMID: 22427645.
Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela T, Moffat J, Hudson TJ, Sladek R. "Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation." Physiological Genomics. 2012 Feb 1; 44(2):183-97. PMID: 22147266.
Rajan S, Djambazian H, Dang HC, Sladek R, Hudson TJ. "The living microarray: a high-throughput platform for measuring transcription dynamics in single cells." BMC Genomics. 2011 Feb 16; 12:115. PMID: 21324195.