Sam Daniel, MD, M.Sc. - Sam Daniel, MD, M.Sc. - Research Institute MUHC
Pediatric otolaryngology • middle ear disease • hearing loss • otoxicity • platinum otoxicity • cisplatin
My research focuses on hearing loss related to middle ear disease, and on ototoxicity, or damage to the ear by drugs, chemicals and noise. Our laboratory also develops animal and computer models of known ear diseases in order to increase our understanding of the pathophysiological processes involved and suggest new therapeutic modalities. This includes diseases caused by middle ear abnormalities and ototoxic medication. Hearing loss is particularly important in children, as it affects the development of their language and social skills. At the McGill Auditory Sciences Laboratory, my research team develops models to further the diagnosis and treatment of drug-induced hearing loss. We are exploring ways to prevent platinum otoxicity, the form of hearing loss experienced by cancer patients. The loss is caused by toxic compounds released after exposure to the chemotherapeutic agent. This research will not only improve the quality of life for cancer survivors; it will also reduce restrictions on some of the most powerful agents used to fight cancer. Controlling the adverse side effect of ototoxicity may allow higher treatment doses of chemotherapy, and consequently better patient survival.
Mujica-Mota MA, Gasbarrino K, Rappaport JM, Shapiro RS, Daniel SJ. The effect of caffeine on hearing in a guinea pig model of acoustic trauma. Am J Otolaryngol. 2013 Dec 7. pii: S0196-0709(13)00280-9. doi: 10.1016/j.amjoto.2013.11.009. [Epub ahead of print]
Zawawi F, Kabbach G, Lallemand M, Daniel SJ. Bone-anchored hearing aid: Why do some patients refuse it? Int J Pediatr Otorhinolaryngol. 2013 Nov 18. pii: S0165-5876(13)00591-0. doi: 10.1016/j.ijporl.2013.11.010. [Epub ahead of print]
Waissbluth S, Daniel SJ. Cisplatin-induced ototoxicity: transporters playing a role in cisplatin toxicity. Hear Res. 299:37-45, 2013 May. doi: 10.1016/j.heares.2013.02.002. Epub 2013 Mar 1.
Waissbluth S, Chan SW, Chen JZ, McIntosh M, Daniel SJ. RNA preservation in decalcified cochlear samples. Otol Neurotol. 34(2):331-7, 2013 Feb. doi: 10.1097/MAO.0b013e318278bf1a.
Marchica CL, Pitaro J, Daniel SJ. Recurrent tube insertion for chronic otitis media with effusion in children over 6 years. Int J Pediatr Otorhinolaryngol. 77(2):252-5, 2013 Feb. doi: 10.1016/j.ijporl.2012.11.010. Epub 2012 Dec 13.