Breadcrumb

null Bertrand Jean-Claude, M.Sc., PhD

Senior Scientist, RI-MUHC, Glen site

Metabolic Disorders and Complications Program

Centre for Translational Biology

Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

Kinase inhibitors • anti-cancer drugs • pharmacokinetics • molecular modeling

Research Focus

My research focuses on the design and synthesis of new drug candidates designed to block multiple pathways in tumour cells.

Selected Publications

Click on Pubmed to see my current publications list

  • Qiu Q, Domarkas J, Banerjee R, Merayo N, Brahimi F, McNamee JP, Gibbs BF, Jean-Claude BJ. The combi-targeting concept: in vitro and in vivo fragmentation of a stable combi-nitrosourea engineered to interact with the epidermal growth factor receptor while remaining DNA reactive. Clin Cancer Res. 2007 Jan 1;13(1):331-40. PMID: 17200372.

  • Senhaji Mouhri Z, Goodfellow E, Kelley SP, Stein RS, Rogers RD, J Jean-Claude B. (15)N-, (13)C- and ¹H-NMR Spectroscopy Characterization and Growth Inhibitory Potency of a Combi-Molecule Synthesized by Acetylation of an Unstable Monoalkyltriazene. Molecules. 2017 Jul 19;22(7). pii: E1183. doi: 10.3390/molecules22071183. PMID: 28753938.

  • Todorova MI, Larroque AL, Dauphin-Pierre S, Fang YQ, Jean-Claude BJ. Subcellular distribution of a fluorescence-labeled combi-molecule designed to block epidermal growth factor receptor tyrosine kinase and damage DNA with a green fluorescent species. Mol Cancer Ther. 2010 Apr;9(4):869-82. doi: 10.1158/1535-7163.MCT-09-0673. Epub 2010 Mar 30. PMID: 20354119.

  • Larroque-Lombard AL, Todorova M, Golabi N, Williams C, Jean-Claude BJ. Synthesis and uptake of fluorescence-labeled Combi-molecules by P-glycoprotein-proficient and -deficient uterine sarcoma cells MES-SA and MES-SA/DX5. J Med Chem. 2010 Mar 11;53(5):2104-13. doi: 10.1021/jm9016043. PMID: 20151639.

  • Rupp M, Mouhri ZS, Williams C, Jean-Claude BJ. Molecular analysis of the dual targeting of the epidermal growth factor receptor and the O(6)-methylguanine-DNA methyltransferase with a double arm hybrid molecule. Oncotarget. 2018 Oct 12;9(80):35041-35055. doi: 10.18632/oncotarget.25120. eCollection 2018 Oct 12. PMID: 30416678.