Michael Zappitelli, MD, M.Sc.
Acute kidney injury • epidemiology • glomerular filtration rate • dialysis • nutrition • critical care nephrology • child health; biomarkers
My research focuses on acute kidney injury (AKI) in children. AKI mostly occurs in hospitalized patients and must be better understood in order to detect the disease earlier, lessen the most serious risks and improve patients' long-term health. Our clinical research laboratory is characterizing this disease by evaluating definitions and performing studies to assess the effect of AKI on various outcomes in several diagnostic populations. Included are patients on nephrotoxic medications, patients undergoing cardiac surgery and critically ill patients. My latest studies examine the long-term outcomes of AKI in cardiac and non-cardiac critically ill patients and in children treated for cancer with cisplatin. I aim to evaluate whether AKI is a risk factor for chronic kidney disease (CKD) and whether new AKI biomarkers of renal tubular damage can be used to better diagnose patients at risk of CKD. Other projects focus on discovering and characterizing novel AKI urine protein biomarkers for AKI diagnosis.
Samuel S, Morgan CJ, Bitzan M, Mammen C, Dart AB, Manns BJ, Alexander RT, Erickson RL, Grisaru S, Wade AW, Blydt-Hansen T, Feber J, Arora S, Licht C, Zappitelli M. Substantial practice variation exists in the management of childhood nephrotic syndrome. Pediatr Nephrol 28(12):2289-98, 2013 Dec. doi:10.1007/s00467-013-2546-0. Epub 2013 Aug 6.
Zappitelli M. Preoperative prediction of acute kidney injury--from clinical scores to biomarkers. Pediatr Nephrol 28(8):1173-82, 2013 Aug. doi: 10.1007/s00467-012-2355-x. Epub 2012 Nov 10.
Zappitelli M, Coca SG, Garg AX, Krawczeski CD, Thiessen Heather P, Sint K, Li S, Parikh CR, Devarajan P; TRIBE-AKI Consortium. The association of albumin/creatinine ratio with postoperative AKI in children undergoing cardiac surgery. Clin J Am Soc Nephrol 7(11):1761-9, 2012 Nov. doi: 10.2215/CJN.12751211.Epub 2012 Aug 23.
Fleming GM, Askenazi DJ, Bridges BC, Cooper DS, Paden ML, Selewski DT, Zappitelli M. A multicenter international survey of renal supportive therapy during ECMO: the Kidney Intervention During Extracorporeal Membrane Oxygenation (KIDMO) group. ASAIO J. 58(4):407-14, 2012 Jul-Aug. doi:10.1097/MAT.0b013e3182579218.
Al-Ismaili Z, Piccioni M, Zappitelli M. Rhabdomyolysis: pathogenesis of renal injury and management. Pediatr Nephrol. 2011 Oct;26(10):1781-8. doi:10.1007/s00467-010-1727-3. Epub 2011 Jan 20. Review.