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Michele Zappitelli, MD, M.Sc.

Research Institute of the McGill University Health Centre

Regular Member
Endocrinology, Diabetes, Nutrition and Kidney Diseases


McGill University Health Centre (MUHC)

Clinician-scientist, Pediatric Acute Kidney Injury Translational Research Laboratory, Montreal Children's Hospital
Director, Dialysis and Apheresis Program, Pediatric Nephrology, Montreal Children's Hospital


McGill University

Assistant Professor of Pediatrics and associate member, Department of Epidemiology, Biostatistics and Occupational Health and Division of Experimental Medicine


Research Interest


My research focuses on acute kidney injury (AKI) in children. AKI mostly occurs in hospitalized patients and must be better understood in order to detect the disease earlier, lessen the most serious risks and improve patients' long-term health. Our clinical research laboratory is characterizing this disease by evaluating definitions and performing studies to assess the effect of AKI on various outcomes in several diagnostic populations. Included are patients on nephrotoxic medications, patients undergoing cardiac surgery and critically ill patients. My latest studies examine the long-term outcomes of AKI in cardiac and non-cardiac critically ill patients and in children treated for cancer with cisplatin. I aim to evaluate whether AKI is a risk factor for chronic kidney disease (CKD) and whether new AKI biomarkers of renal tubular damage can be used to better diagnose patients at risk of CKD. Other projects focus on discovering and characterizing novel AKI urine protein biomarkers for AKI diagnosis.

Research Foci


  • glomerular filtration rate estimation;
  • epidemiology of acute kidney injury;
  • diagnostic testing in acute kidney injury;
  • long-term acute kidney injury outcomes;
  • hypertension evaluation

Keywords


Acute kidney injury, epidemiology, glomerular filtration rate, dialysis, nutrition, critical care nephrology, child health; biomarkers

Selected Publications


  • Samuel S, Morgan CJ, Bitzan M, Mammen C, Dart AB, Manns BJ, Alexander RT, Erickson RL, Grisaru S, Wade AW, Blydt-Hansen T, Feber J, Arora S, Licht C, Zappitelli M. Substantial practice variation exists in the management of childhood nephrotic syndrome. Pediatr Nephrol 28(12):2289-98, 2013 Dec. doi:10.1007/s00467-013-2546-0. Epub 2013 Aug 6.

  • Zappitelli M. Preoperative prediction of acute kidney injury--from clinical scores to biomarkers. Pediatr Nephrol 28(8):1173-82, 2013 Aug. doi: 10.1007/s00467-012-2355-x. Epub 2012 Nov 10.

  • Zappitelli M, Coca SG, Garg AX, Krawczeski CD, Thiessen Heather P, Sint K, Li S, Parikh CR, Devarajan P; TRIBE-AKI Consortium. The association of albumin/creatinine ratio with postoperative AKI in children undergoing cardiac surgery. Clin J Am Soc Nephrol 7(11):1761-9, 2012 Nov. doi: 10.2215/CJN.12751211.Epub 2012 Aug 23.

  • Fleming GM, Askenazi DJ, Bridges BC, Cooper DS, Paden ML, Selewski DT, Zappitelli M. A multicenter international survey of renal supportive therapy during ECMO: the Kidney Intervention During Extracorporeal Membrane Oxygenation (KIDMO) group. ASAIO J. 58(4):407-14, 2012 Jul-Aug. doi:10.1097/MAT.0b013e3182579218.

  • Al-Ismaili Z, Piccioni M, Zappitelli M. Rhabdomyolysis: pathogenesis of renal injury and management. Pediatr Nephrol. 2011 Oct;26(10):1781-8. doi:10.1007/s00467-010-1727-3. Epub 2011 Jan 20. Review.