Ernest Seidman, MD - Research Institute of the McGill University Health Centre
IBD • Crohn's disease • ulcerative colitis • celiac disease • translational research • genetics • colon cancer • autoimmune • intestinals
My research focuses on obtaining a better understanding of how immune system dysfunction results in "autoimmune" bowel disorders such as Crohn's disease, ulcerative colitis and celiac disease. My laboratory employs several complimentary research strategies, including cultured cell lines, experimental animal models, as well as bowel explants or isolated human cells from human gut biopsies or intestinal resections. In addition to studying the causes of these disorders, my research also focuses on non-invasive measures to detect and follow these disorders, as well as novel approaches to their treatment and prevention.
S Dionne, MR Calderone, J White, B Memari, B Adelson, C Piccirillo, EG Seidman. Differential effect of vitamin D on NOD2-and TLR-induced cytokines in Crohn's disease. Mucosal Immunology 2014
Dionne S, Elimrani I, Roy MJ, Qureshi IA, Sarma DR, Levy E, Seidman EG Studies on the chemopreventive effect of carnitine on tumorigenesis in vivo, using two experimental murine models of colon cancer. Nutr Cancer 2012;64(8):1297-87.
Dassopoulos T, Dubinsky M, Bentsen J, Martin C, Galanko J, Seidman E, Sandler R, Hanauer S. A Randomized Trial of Individualized versus Weight-Based Dosing of Azathioprine in Crohn's Disease. Aliment Pharmacol Ther 2014; 39: 163-175.
Girardin M, Dionne S, Goyette P, Rioux J, Bitton A, Elimrani I, Charlebois P, Qureshi I, Levy E, Seidman EG. Expression and functional analysis of intestinal organic cation/L-carnitine transporter (OCTN) in Crohn's disease. J Crohn's & Colitis 2012;6(2):189-97.
Silva MA, Menezes J, Dionne S, Levy E, Amre DK, Seidman EG. Herpes Simplex Virus-1 infection of colonic explants as a model of viral induced activation of Crohn's disease. J Crohn's & Colitis 2012 May;6(4) :454-63