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angle-left Geoffrey Hendy, PhD

Senior Scientist, RI-MUHC , Glen site

Metabolic Disorders and Complications Program

Centre for Translational Biology

Professor, Department of Medicine, Faculty of Medicine, McGill University



Calcium homeostasis • molecular diagnostics • endocrine • functional analysis

Research Focus

My research focuses on the molecular genetics of mineral metabolism disorders with a focus on functional analysis of inherited mutations in genes controlling blood calcium and skeletal homeostasis.

In Memoriam

Selected Publications

Click on Pubmed to see my current publications list

  • Puzhko, S., Goodyer, C.G., Kerachian, M.A., Canaff, L., Misra, M., Jüppner, H., Bastepe, M., Hendy, G.N. Parathyroid hormone signaling via Gas is selectively inhibited by an NH2-terminally truncated Gas: implications for pseudohypoparathyroidism. J. Bone Miner. Res. 26:2473-2485, 2011.

  • Canaff, L., Vanbellinghen, J-F., Kanazawa, I., Kwak, H., Garfield, N., Vautour, L., Hendy, G.N. Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: restoration of expression and activity by CHIP siRNA. J. Clin. Endocrinol. Metab. 97:E282-E291, 2012.

  • Canaff, L., Vanbellinghen, J-F., Kaji, H., Goltzman, D., Hendy, G.N. Impaired transforming growth factor-beta (TGF-b) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with Multiple Endocrine Neoplasia type 1 (MEN1). J. Biol. Chem. 287:8584-8597, 2012.

  • Hendy, G.N., Canaff, L., Cole, D.E.C. The CASR gene: Alternative splicing and transcriptional control, and calcium-sensing receptor (CaSR) protein: Structure and ligand binding sites. Best Pract Res Clin Endocrinol Metab 27: 285-301, 2013

  • Hendy, G.N., Cole, D.E.C. Invited Editorial. Ruling in a suspect: the role of AP2S1 mutations in familial hypocalciuric hypercalcemia type 3. J. Clin. Endocrinol. Metab. In press. 2013.