Breadcrumb

null Guy Rutter, PhD

Affiliate Investigator, RI-MUHC

 

Keywords

Diabetes • pancreas • islet • beta cell • insulin secretion • imaging • mitochondria • calcium

Research Focus

Diabetes mellitus affects more than 3 million Canadians and 450 million people worldwide. My research focuses on the biology of the pancreatic β-cell, responsible for the production of insulin. All forms of diabetes mellitus involve changes in the number or the activity of these cells. Using preclinical models and in vivo imaging technologies, I explore the role of genes associated with Type 1 and Type 2 diabetes, their molecular mechanisms of action and their potential as targets for therapy. My research is supported by the Wellcome Trust, CIHR and NIH.

Selected Publications

Click on Pubmed to see my current publications list

  • Delgadillo Silva, L.F., Tasoz, E., Singh, S.P., Chawla, P., Georgiadou, E., Gompf, A., Rutter, G.A.* and Ninov, N. Optical interrogation of β-cell activity in situ identifies two highly functional subpopulations of pancreatic β-cells. Sci Adv. 2024 Jun 28;10(26):eado4513. doi: 10.1126/sciadv.ado4513. Epub 2024 Jun 26. PMID: 38924394.

  • Slieker, R.C. A Donnelly, L.A., Akalestou, E., Lopez-Noriega, Livia, Melhem R., Güneş A., Abou Azar, F., Efanov, A., Georgiadou, E., Muniangi-Muhitu, H., Sheikh, M., Giordano, G.N., Åkerlund, M., Ahlqvist, E., Ali, A., Banasik, K., Brunak, S., Marko Barovic, M., Bouland, G.A., Burdet, F., Canouil, M., Dragan, I., JM Elders, P.J.M., Fernandez, C., Festa, A., Fitipaldi, H., Froguel, P., Gudmundsdottir, V., Gudnason, V., Gerl, M.J., A. van der Heijden, A.A., Jennings, L.L.,. Hansen, M.K., Kim, M., Leclerc I., Klose, C., Kuznetsov, D., Mansour Aly, D., Mehl, F., Marek, D., Melander, O., Niknejad, A., Ottosson, F., Pavo, I., Duffin, K., Syed, S.K., Shaw, J.L., Cabrera, O., Pullen, T.J., Simons, K., Solimena, M., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido Quigley, C., Groop, L., Thorens, B., Franks, P.W., Lim, G.E., Estall, J.E., Ibberson, M., WJ Beulens, J.W.J., ’t Hart, L.M., Pearson, E.R. and Rutter, G.A. Biomarkers for glycaemic deterioration in type 2 diabetes. Nat Commun. 2023 May 3;14(1):2533. doi: 10.1038/s41467-023-38148-7.PMID: 37137910.

  • Salem, V., Delgadillo Silva, L-F., Suba, K., Georgiadou, E., Mousavy, N., Akhtar, N., Martin-Alonso, A., Gaboriau, D.C.A., Rotheray, S., Stylianides, T., Carrat, G.C., Pullen, T.J., Pal Singh, S., Hodson, D.J., Leclerc, I., Shapiro, A.M. James, Marchetti, P., Briant, L.J.B., Distaso, W., Ninov, N. and Rutter, G.A. Leader beta cells coordinate Ca2+ dynamics across pancreatic islets in vivo. Nature Metabolism 1, 625-629 (2019) PMID: 32694805.

  • Johnston, N.R., Mitchell, R.K., Haythorne, E., Pessoa, Maria Paiva, Semplici, F., Ferrer, J., Piemonti, L., Marchetti, P., Bugliani, M., Bosco, D., Berishvili, E., Duncanson, P., Watkinson, M., Broichhagen, J., Trauner, D., Rutter, G.A.* and Hodson D.J. Beta cell hubs dictate pancreatic islet responses to glucose. Cell Metabolism 24(3):389-401 pii: S 1550-4131(16)30306-0. doi: 10.1016/j.cmet.2016.06.020. (2016). PMID: 32694805.

  • Rutter, G.A., Burnett, P. Rizzuto, R., Brini, M., Pozzan, T., Tavaré, J.M. and Denton, R.M. Digital imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity. Proc. Natl. Acad. Sci. [IF=9.598] 93, 5489-5494 (1996) doi: 10.1073/pnas.93.11.5489. PMID: 8643602.