null Inés Colmegna, MD
rheumatology • arthritis • vaccine responses in rheumatology patients • stem and progenitor cells • aging • immunology
My research focuses on evaluating the mechanisms underlying the development and perpetuation of the most common form of inflammatory polyarthritis: rheumatoid arthritis. Specifically, my group studies the impact of aging on human immune and stem/progenitor cell function. This will help in understanding the interplay of aging with immune tolerance and the risk of developing autoimmune disorders. In addition, we are interested in evaluating how protective responses generated by vaccines can be enhanced in people with rheumatologic conditions. This will help in reducing the morbidity and mortality of vaccine preventable diseases in this vulnerable group.
Valerio V, Bazan MC, Wang M, Mazer BD, Pineau CA, Hazel EM, Bernatsky S, Ward BJ, Colmegna I. A multimodal intervention increases influenza vaccine uptake in rheumatoid arthritis. Clin Rheumatol 2021;40(2):575-579.
Colmegna I, Useche ML, Rodriguez K, McCormack D, Alfonso G, Patel A, Ramanakumar AV, Rahme E, Bernatsky B, Hudson M, Ward BJ. MDImmunogenicity and safety of high-dose versus standard-dose inactivated influenza vaccine in rheumatoid arthritis patients: a randomised, double-blind, active-comparator trial. The Lancet Rheumatology 2020; 12(1):E14-E23.
Cheng A, Choi D, Lora M, Shum-Tim D, Rak J, Colmegna I. Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo. Stem Cell Res Ther 2020;11(1):539.
Kizilay Mancini O, Lora M, Cuillerier A, Shum-Tim D, Hamdy R, Burelle Y, Servant MJ, Stochaj U, Colmegna I. Mitochondrial oxidative stress reduces the immunopotency of mesenchymal stromal cells in adults with coronary artery disease. Circ Res 2018;122(2):255-266.