null Inés Colmegna, MD

Scientist, RI-MUHC , Glen site

Infectious Diseases and Immunity in Global Health Program

Centre for Translational Biology

Associate Professor, Department of Medicine, Faculty of Medicine, McGill University

Department of Medicine, Division of Rheumatology, MUHC



immunology • arthritis • aging • stem cells

Research Focus

My research focuses on understanding the mechanisms underlying the development and perpetuation of the most common form of inflammatory polyarthritis: rheumatoid arthritis. Specifically, we study the impact of aging on human immune and stem cell function and how aging promotes the disruption of immune tolerance increasing the risk of developing autoimmune disorders.

Selected Publications

Click on Pubmed to see my current publications list

  • Stochaj U, Kodiha M, Shum-Tim D, Colmegna I. Implications of multipotent mesenchymal stromal cell aging. Regen Med. 2013 Mar;8(2):211-22. PMID: 23477400.

  • Colmegna I, Ohata BR, Menard HA. Current understanding of rheumatoid arthritis therapy. Clin Pharmacol Ther. 2012 Apr;91(4):607-20. PMID: 22357455.

  • Colmegna I, Pryshchep S, Oishi H, Goronzy JJ, Weyand CM. Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritis. Clin Immunol. 2012 Apr;143(1):73-82. PMID: 22342385.

  • Colmegna I, Weyand CM. Haematopoietic stem and progenitor cells in rheumatoid arthritis. Rheumatology (Oxford). 2011 Feb;50(2):252-60. PMCID: PMC3021951.

  • Colmegna I, Diaz-Borjon A, Fujii H, Schaefer L, Goronzy JJ, Weyand CM. Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis. Arthritis Rheum. 2008 Apr;58(4):990-1000. PMID: 18383391.