null Jeremy Van Raamsdonk, PhD, M.Sc
aging • biological resilience • neurodegeneration • Parkinson's disease • Huntington's disease • mitochondria • animal models • C. elegans • stress resistance • oxidative stress • reactive oxygen species
My research focuses on the genetics and biology of aging and the pathogenesis of neurodegenerative disease. I am also highly interested in biological resilience and how that contributes to longevity and neurodegeneration. Much of my work focusses on the mitochondria as it is highly involved in lifespan, resilience and neurodegenerative disease. To complete these studies, I primarily use a simple genetic model organism, the worm C. elegans. My work in geroscience aims to advance our understanding of the molecular mechanisms underlying longevity and biological resilience and apply that knowledge to promote healthy aging and develop novel treatments for neurodegenerative disease. I use a translational approach in which we perform initial experiments in C. elegans in order to prioritize subsequent experiments in mammalian models.
Endosomal trafficking protein TBC-2 modulates stress resistance and lifespan through DAF-16-dependent and independent mechanisms. Annika Traa, Sonja K Soo, Abdelrahman AlOkda, Bokang Ko, Christian E Rocheleau, Jeremy M Van Raamsdonk. Aging Cell. 2023, February. PMID: 36794357.
Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics. Juliane Cruz Campos, Luiz Henrique Marchesi Bozi, Barbara Krum, Luiz Roberto Grassmann Bechara, Nikolas Dresch Ferreira, Gabriel Santos Arini, Rudá Prestes Albuquerque, Annika Traa, Takafumi Ogawa, Alexander M van der Bliek, Afshin Beheshti , Edward T Chouchani, Jeremy M Van Raamsdonk, T Keith Blackwell, Julio Cesar Batista Ferreira. Proc Natl Acad Sci U S A. 2023 January. PMID: 36595699.
Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity. Sonja K Soo, Annika Traa, Zenith D Rudich, Alibek Moldakozhayev, Meeta Mistry, Jeremy M Van Raamsdonk. Aging Cell. 2022 December. PMID: 36514863.
Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants. Namastheé Harris-Gauthier, Annika Traa, Abdelrahman AlOkda, Alibek Moldakozhayev, Ulrich Anglas, Sonja K Soo, Jeremy M Van Raamsdonk. Redox Biol. 2022 May. PMID: 35598379.
Mild mitochondrial impairment enhances innate immunity and longevity through ATFS-1 and p38 signaling. Campos JC, Wu Z, Rudich PD, Soo SK, Mistry M, Ferreira JC, Blackwell TK, Van Raamsdonk JM. EMBO Rep. 2021 Oct 7:e52964. doi: 10.15252/embr.202152964. Online ahead of print. PMID: 34617666.