innate immunity • cell death • infection • cancer • inflammatory diseases
My research focuses on key pathways of innate immunity and cell death with an aim to uncovering new biologic therapies for inflammatory-mediated immune disorders. My lab explores the molecular mechanisms and roles of cytosolic Pattern Recognition Receptors in host defense, diseases of chronic inflammation, and cancer. My group has undertaken systems biology approaches including proteomics and large-scale genome-wide RNA interference screens to identify molecular networks that regulate innate immunity. With unique genetic tools and experimental models of disease, the lab explores the crosstalk between the innate immune system and the environment including our microbiota in intestinal homeostasis, immune tolerance, and chronic inflammatory diseases including cancer and metabolic diseases.
Dupaul-Chicoine J, Arabzadeh A, Dagenais M, Douglas T, Champagne C, Morizot A, Rodrigue-Gervais IG, Breton V, Colpitts SL, Beauchemin N, Saleh M. The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity. Immunity. 2015 Oct 20;43(4):751-63. doi: 10.1016/j.immuni.2015.08.013. Epub 2015 Sep 15. PMID: 26384545.
Douglas T, Champagne C, Morizot A, Lapointe JM, Saleh M. The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice. J Immunol. 2015 Sep 1;195(5):2365-73. doi: 10.4049/jimmunol.1500542. Epub 2015 Jul 27. PMID: 26216893.
Dagenais M, Dupaul-Chicoine J, Champagne C, Skeldon A, Morizot A, Saleh M. A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. Mucosal Immunol. 2015 Jun 3. doi: 10.1038/mi.2015.46. [Epub ahead of print] PMID: 26037070.
LeBlanc PM, Doggett TA, Choi J, Hancock MA, Durocher Y, Frank F, Nagar B, Ferguson TA, Saleh M. An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor. J Biol Chem. 2014 Mar 14;289(11):7777-86. doi: 10.1074/jbc.M113.541474. Epub 2014 Jan 28. PMID: 24474694.
Rodrigue-Gervais IG, Labbé K, Dagenais M, Dupaul-Chicoine J, Champagne C, Morizot A, Skeldon A, Brincks EL, Vidal SM, Griffith TS, Saleh M. Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival. Cell Host Microbe. 2014 Jan 15;15(1):23-35. doi: 10.1016/j.chom.2013.12.003. PMID: 24439895.