null Vassilios Papadopoulos, PhD
steroids • neurosteroids • pharmacology • drug discovery • endocrinology
Vassilios Papadopoulos received an Honorary Investigator appointment to the Research Institute of the McGill University Health Centre (RI-MUHC) in 2022. This appointment recognizes his distinguished contributions in multiple roles: as former Executive Director and Chief Scientific Officer of the RI-MUHC, senior scientist in the Metabolic Disorders and Complications Program, holder of the Phil Gold Chair at McGill University, and mentor of numerous investigators and trainees. His vital role in obtaining Canada Foundation for Innovation funding for new research facilities at the Glen site, overseeing the move and establishing a new program structure have left an enduring legacy at the RI-MUHC.
His laboratory is recognized for innovative studies on cellular and molecular mechanisms responsible for the initiation and maintenance of steroid biosynthesis in the gonads, adrenal, and brain, in health and disease. This research aims to understand the pathophysiology of steroidogenesis, develop new tools for the treatment of diseases related to elevated or low steroid levels, and alter subcellular steroid compartmentalization as a means to block disease acquisition and/or its progression.
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Fan J, Campioli E, Midzak A, Culty M, Papadopoulos V. Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7261-6. PMID: 26039990.
Martinez-Arguelles DB, Papadopoulos V. Identification of hot spots of DNA methylation in the adult male adrenal in response to in utero exposure to the ubiquitous endocrine disruptor plasticizer di-(2-ethylhexyl) phthalate. Endocrinology. 2015 Jan;156(1):124-33. PMID: 25330100.
Aghazadeh Y, Ye X, Blonder J, Papadopoulos V. Protein modifications regulate the role of 14-3-3γ adaptor protein in cAMP-induced steroidogenesis in MA-10 Leydig cells. J Biol Chem. 2014 Sep 19;289(38):26542-53. PMID: 25086053.
Rone MB, Midzak AS, Issop L, Rammouz G, Jagannathan S, Fan J, Ye X, Blonder J, Veenstra T, Papadopoulos V. Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hormones. Mol Endocrinol. 2012;26:1868-82. PMID: 22973050.
Rammouz G, Lecanu L, Aisen P, Papadopoulos V. A lead study on oxidative stress-mediated dehydroepiandrosterone formation in serum: the biochemical basis for a diagnosis of Alzheimer's disease. J Alzheimers Dis. 2011;24:5-16. PMID: 21335661.