null William Muller, B.Sc., PhD

Investigator, RI-MUHC

Cancer Research Program

Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University



breast cancer • transgenic mouse models • oncogenes

Research Focus

My research focuses on elucidating the mechanism by which oncogenes induce breast cancer.

Selected Publications

Click on Pubmed to see my current publications list

  • Sriram R, Lo V, Pryce B, Antonova L, Mears AJ, Daneshmand M, McKay B, Conway SJ, Muller WJ, Sabourin LA. Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity. Breast Cancer Res. 2015 Jan 16;17:7. doi: 10.1186/s13058-014-0513-8. PMID: 25592291.

  • Roovers K, Wagner S, Storbeck CJ, O'Reilly P, Lo V, Northey JJ, Chmielecki J, Muller WJ, Siegel PM, Sabourin LA. The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility. Oncogene. 2009 Aug 6;28(31):2839-48. doi: 10.1038/onc.2009.146. Epub 2009 Jun 15. PMID: 19525980.

  • Lahlou H, Sanguin-Gendreau V, Frame MC, Muller WJ. Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo. Breast Cancer Res. 2012 Feb 28;14(1):R36. PMID: 22373082.

  • Lahlou H, Muller WJ. &beta1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer. Breast Cancer Res. 2011;13(6):229. doi: 10.1186/bcr2905. Epub 2011 Nov 30. Review. PMID: 22264244.

  • Klimcakova E, Chénard V, McGuirk S, Germain D, Avizonis D, Muller WJ, St-Pierre J. PGC-1α promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply. Cancer Res. 2012 Mar 15;72(6):1538-46. doi: 10.1158/0008-5472.CAN-11-2967. Epub 2012 Jan 19. PMID: 22266114.