cancer • human development • epigenetics • molecular biology
My research focuses on the epigenetic basis of cancer, stem cells and human development, especially about how cellular signaling regulates cell growth and differentiation, how the genetic material is elegantly organized in human cells, how gene activities are controlled, and how these events become abnormal in cancer and other diseases. We have been using cutting-edge molecular biology techniques and characterizing genetically modified mouse models to investigate these important issues. In addition, we have been also interested in generating different stem cells by somatic cell reprogramming. The research has provided, and will continue to yield, new insights into how to develop novel means for prevention, diagnosis and treatment of related human diseases.
Tahmasebi, S., Alain, T., Rajasekhar, V.K., Zhang, J.P., Prager-Khoutorsky, M., Khoutorsky, A., Dogan, Y., Gkogkas, C.G., Petroulakis, E., Sylvestre, A., Assadian, S., Yamanaka, Y., Vinagolu Baur, J.R., Teodoro, J.G., Kim, K., Yang, X.J.* and Sonenberg, N.* (2014) Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell Stem Cell 14, 606-16 (*, corresponding author). PMID: 24630793.
You, L., Zou, J., Zhao, H., Bertos, N.R., Park, M., Wang, E. and Yang, X.J. (2015). Deficiency of the chromatin regulator Brpf1 causes abnormal brain development. J. Biol. Chem. 290, 7114-7129. PMID: 25568313.
You, L., Yan, K., Zou, J., Zhao, H., Bertos, N.R., Park, M., Wang, E. and Yang, X.J. (2015). The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors. PLoS Genet. 11, e1005034. PMID: 25757017.
You, L., Yan, K., Zou, J., Zhao, H., Bertos, N.R., Park, M., Wang, E. and Yang, X.J. (2015) The chromatin regulator Brpf1 regulates embryo development and cell proliferation. J. Biol. Chem., doi/10.1074/jbc.M115.643189 [Epub ahead of print on March 15]. PMID: 25773539.
Nie, J., Xu, C., Jing, J., Aka, J., Tempel, W., Nguyen, V., You, L., Weist, R., Min, J., Pawson, T. and Yang, X.J. (2015) Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. Structure 23, 700-12. PMID: 25752541.