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null Barry Posner, OC, CQ, MD, FRSC, FRCPC, FACP

Honorary Investigator, RI-MUHC, Glen site

Centre for Translational Biology

Emeritus Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

Receptor • cell signaling • endosomes • tyrosine kinase • phosphotyrosine phosphatase

Research Focus

Barry Posner received an Honorary Investigator appointment to the Research Institute of the McGill University Health Centre in 2021 in light of his distinguished contributions as a researcher, professor, and leader. This is exemplified by his globally recognized work on growth factor signaling mediated by receptor tyrosine kinases and their intracellular trafficking. Specifically, his laboratory discovered the role of internalization of ligand-receptor complexes into endosomes (ENs), the delineation of a key role for phosphotyrosine phosphatases in regulating receptor tyrosine kinase function (notably that of the insulin receptor kinase) within ENs, and the identification of new molecules in the pathway of insulin and EGF signaling, including IRS3, Gab2, and SHPTP1. This has been appropriately recognized by numerous awards, including fellowship in the Royal Society of Canada and the Canadian Academy of Health Sciences and induction into the Order of Canada and the Order of Quebec.

Selected Publications

Click on Pubmed to see my current publications list

  • Posner, B.I. Insulin Signaling – The Inside Story. Can.Journal of Diabetes 41: 108-114, 201. doi: 10.1016/j.jcjd.2016.07.002. PMID: 27614806.

  • Posner, B.I., R. Faure, J.W. Burgess, A.P. Bevan, D. Lachance, G. Zhang-Sun, I.G. Fantus, J.B. Ng, D.A. Hall, B. Soo Lum, and A. Shaver. Peroxovanadium Compounds: A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetic. J. Biol. Chem. 269: 4596-4604, 1994. PMID: 8308031.

  • Shen, S.H., L. Bastien, B.I. Posner and P. Chretien. A protein tyrosine phosphatase with sequence similarity to the SH2 domain of the protein tyrosine kinases. Nature 352: 736-739, 1991. DOI: 10.1038/352736a0. PMID: 1652101.

  • Tannenbaum, G.S., H.J. Guyda and B.I. Posner. Insulin-like growth factors: A role in growth hormone negative feedback and body weight regulation via the brain. Science 220: 77-79, 1983. DOI: 10.1126/science.6338593. PMID: 6338593.

  • Van Houten, M., B.I. Posner, B.M. Kopriwa and J.R. Brawer. Insulin binding sites localized to nerve terminals in rat median eminence and arcuate nucleus. Science 207: 1081-1083, 1980. DOI: 10.1126/science.6986652. PMID: 6986652.