Où : Institut de recherche du Centre universitaire de santé McGill (IR-CUSM), site Glen, Bloc E, salle M1.3509, 1001, boul. Décarie, Montréal, Québec, H4A 3J1

Quand : mercredi le 12 février de 12 h à 13 h

Conférencier : Mohammad-Ali Jenabian DVM, PhD
Canada Research Chair in Immuno-Virology
Associate Professor in Immunology, Dept Biological Sciences, Université du Québec à Montréal
Adjunct Professor, Dept Microbiology & Immunology, McGill University

« Regulatory T cells in HIV infection: The wearer of many hats »

« Regulatory T-cells (Tregs) play a pivotal role in the control of immune tolerance and autoimmune diseases. HIV infection is associated with an increase in Treg activation and frequencies. Whether Tregs play a beneficial or detrimental role in HIV infection remains controversial as Tregs can suppress HIV-specific responses contributing to viral persistence, and conversely, can have a beneficial role by reducing deleterious immune activation. Here, the following points will be discussed: (1) various immuno-modulatory roles played by Tregs during HIV/SIV infections, (2) molecular and epigenetic mechanisms involved in the regulation and maintenance of Tregs during HIV infection, and, (3) paradoxical dynamics of circulating versus tissues resident Tregs during HIV/SIV infections. »

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