Breadcrumb

null Adam Shapiro, MD

Associate Investigator, RI-MUHC, Glen site

Child Health and Human Development Program

Associate Professor, Department of Pediatrics, Faculty of Medicine and Health Sciences, McGill University

Department of Pediatrics, Division of Respiratory Medicine, MUHC

 

Keywords

Primary ciliary dyskinesia • nitric oxide • Kartagener • cilia • heterotaxy • situs

Research Focus

My research focuses on chronic lung diseases, such as primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) in children and adults. I am actively engaged in new gene discoveries for PCD, as well as deep phenotyping of existing clinical features in PCD, such as organ laterality issues. I also participate in numerous pharmaceutical trials for novel therapeutic agents to treat both PCD and CF.

Selected Publications

Click on Pubmed to see my current publications list

  • Shapiro AJ, Davis SD, Polineni D, et al. Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline. American journal of respiratory and critical care medicine 2018; 197: e24-e39. PMID: 29905515.

  • Shapiro AJ, Davis SD, Ferkol TF, et al. Laterality defects other than situs inversus totalis in primary ciliary dyskinesia: Insights into situs ambiguus and heterotaxy. Chest. 2014 Nov 1;146(5):1176-86. doi: 10.1378/chest.13-1704. PMID: 24577564.

  • Shapiro AJ, Josephson M, Rosenfeld M, et al. Accuracy of Nasal Nitric Oxide Measurement as a Diagnostic Test for Primary Ciliary Dyskinesia. A Systematic Review and Meta-analysis. Annals of the American Thoracic Society 2017; 14: 1184-1196. PMID: 28481653.

  • Shapiro AJ, Zariwala MA, Ferkol T, et al. Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review. Pediatric Pulmonology 2016; 51: 115-132. PMID: 26418604.

  • Sanders CD, Leigh MW, Chao KC, Weck KE, King I, Wolf WE, Campbell DJ, Knowles MR, Zariwala MA, Shapiro AJ. The prevalence of the defining features of primary ciliary dyskinesia within a cri du chat syndrome cohort. Pediatr Pulmonol. 2018 Sep 20. doi: 10.1002/ppul.24159. [Epub ahead of print]. PMID: 30238669.