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Funding results

 

Canada's Top 40 Research Hospitals

FALL 2023 CIHR COMPETITION RESULTS

Researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) will embark on 21 new projects designed to accelerate discoveries of benefit to human health, thanks to the Canadian Institutes of Health Research (CIHR) Fall 2023 Project Grants Competition. The RI-MUHC teams received over $13.65 million in project funding.

Across Canada, the competition has approved 374 research grants plus six bridge grants for a total investment of approximately $325 million. In addition, 150 priority announcement grants were funded for a total amount of over $16.42 million and 14 supplemental prizes were awarded for a total of $450K.

Congratulations to RI-MUHC grant recipients and their teams!

PROJECT GRANTS

  • Carolyn Baglole
    Decoding how the aryl hydrocarbon receptor (AhR) controls cigarette smoke-induced lung inflammation and development of chronic obstructive pulmonary disease (COPD)
  • Yen-I Chen, Nauzer Forbes
    A novel through-the-scope exchangeable double balloon catheter to guide endoscopic bypass: a practice-changing technology in the management of malignant gastric outlet obstruction
  • Nathalie Lamarche-Vane
    Netrin-1 receptor "deleted in colorectal cancer" (DCC) signalosome in axonal development
  • Monzur Murshed
    Understanding how a novel mutation in matrix Gla protein causes skeletal anomalies
  • Cristian O'Flaherty
    Sperm capacitation: A brand new perspective to tackle idiopathic male infertility
  • Madhukar Pai
    Empowering informal healthcare providers to detect tuberculosis using tongue swabs: a field-based, open-label, cluster randomized trial in India
  • Ciriaco A. Piccirillo
    Modelling of human FOXP3+ regulatory T cell functional development in health and disease using artificial thymic organoids.
  • Christian E. Rocheleau
    Understanding polarized EGFR trafficking and signal regulation by RAB-10/8 and AP-1
  • Shaifali Sandal
    A health systems approach to improve the care of kidney transplant recipients with graft failure
  • Per Jesper Sjöström
    Unconventional NMDAR Signalling
  • Per Jesper Sjöström
    Neocortical Circuits in Health and Disease
  • Tomoko Takano, Ciriaco A. Piccirillo
    Pathogenesis of idiopathic nephrotic syndrome: defining the role of B cells and autoantibodies reactive to podocyte proteins
  • George Thanassoulis
    Genomics of Aortic Stenosis - An International Collaboration
  • Rhian M. Touyz
    Vascular redox signaling and Nox5 define the vasculome in hypertension
  • Jacquetta M. Trasler
    Detecting and preventing epigenetic defects and adverse health outcomes associated with assisted reproduction

PRIORITY ANNOUNCEMENTS

Pandemic Preparedness and Health Emergencies

  • Andrea Benedetti, Brett D. Thombs
    Recovering from the COVID-19 Pandemic, Informing Future Public Health Crises, and Building a Global Evidence Base for Mental Health Research: A Systematic Review of COVID-19-related Mental Health

Project Grant - Priority Announcement: Health and Climate Change

  • Sasha R. Bernatsky, Hong Chen, Audrey Smargiassi, Juan A. Avina-Zubieta
    Environmental factors and risk of autoimmune rheumatic disease incidence and serology

Sex and Gender in Health Research (Bridge funding)

  • Stella S. Daskalopoulou
    Identifying the Role of Sex Hormones in Carotid Atherosclerotic Plaque Instability

Research in human development, child and/or youth health in Indigenous populations

  • Patricia T. Li, Ryan Giroux, Matthew Carwana, Gita Wahi, Tania Principi, Samina Ali, Ananya T. Banerjee, Evelyn Constantin, Ugochinyere Viv Ukah, Brett S. Burstein, Suzette R. Cooke, Gabrielle Freire, Christina I. Maratta, Jessica L. Foulds, Olivier Drouin, Nathalie Orr-Gaucher, April Kam, Shazeen Suleman
    Race, Ethnicity, Indigenous identity and Language preference for Pediatric research in the hospital setting (REIaL-P)

HIV/AIDS and STBBI

  • Nitika Pai, Qihuang Zhang, Samira Abbasgholizadeh Rahimi, Nora Engel, Suma Nair, Susan J. Bartlett
    Feasibility of AnkaSmart!: a wearable-based innovation to improve sexual and reproductive health of young adult populations in India

Aging

  • Jeremy Van Raamsdonk
    Role of biological resilience pathways in longevity and neuroprotection

Learn more on the Canadian Institutes of Health Research website

—Published February 16, 2024

 


 

CANADA RESEARCH CHAIRS, SPRING 2023

Tier 1 Canada Research Chairs are awarded to outstanding researchers acknowledged by their peers as world leaders in their fields. Congratulations to Dr. Rhian Touyz, who earned the Tier 1 Canada Research Chair in Cardiovascular Medicine in the spring 2023 competition!

Dr. Touyz is the Executive Director and Chief Scientific Officer of the Research Institute of the McGill University Health Centre and a senior scientist in the Cardiovascular Health Across the Lifespan Program. She holds the Dr. Phil Gold Chair in Medicine and Professor in Family Medicine at McGill University.

The Canada Research Chairs Program stands at the centre of a national strategy to make Canada one of the world's top countries in research and development. It invests approximately $311 million per year to attract and retain a diverse cadre of world-class researchers, to reinforce academic research and training excellence in Canadian postsecondary institutions.

Learn more about the competition results for McGill University in the McGill Reporter

—Published August 31, 2023

 


 

SPRING 2023 CIHR COMPETITION RESULTS

Researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) will lead 15 new projects designed to accelerate discoveries of benefit to human health, thanks to the Canadian Institutes of Health Research (CIHR) Spring 2023 Project Grants Competition. The RI-MUHC teams received over $16.5 million in project funding.

Across Canada, the competition has approved 381 research grants for a total investment of approximately $325 million. In addition, 62 priority announcement grants were approved for a total of $7.2 million, along with 12 bridge grants totalling $1.2 million and five supplemental prizes totalling $250,000.

Congratulations to RI-MUHC grant recipients and their teams!

PROJECT GRANTS

  • Geneviève Bernard
    RNA polymerase III-related leukodystrophy: Understanding disease pathogenesis and developing novel therapeutic approaches using murine models
  • Julia Burnier
    Modelling cancer cell-derived extracellular vesicles using synthetic nanoparticles
  • Jonathon Campbell, James C. Johnston, Sarah K. Brode
    A Key Step to Eliminating Tuberculosis in Canada: Informing the Implementation and Scale-up of Tuberculosis Preventive Treatment
  • Julio F. Fiore Jr., Justin Rivard, May Lynn Quan, Jad Abou Khalil, Christine Desbiens, Emily G. McDonald, Liane S. Feldman, Ipshita Prakash, Stephanie M. Wong, Sarkis H. Meterissian, Allison Maciver, Lisa Findlay-Shirras
    Comparative effectiveness of opioid versus opioid-free post-discharge analgesia after outpatient breast surgery: A randomized controlled trial
  • Catherine Goudie
    Leveraging precision medicine and eHealth to predict cancer predisposition syndromes in children: A Canadian initiative to redress global health disparities in cancer genetics
  • Ariane Marelli
    Exposure to Low Dose Ionizing Radiation In Adult Patients with Congenital Heart Disease - A Time Series Analysis Assessing the Past and Projecting the Future
  • James G. Martin
    Understanding the Mechanistic Basis of Irritant-Induced Airway Dysfunction
  • Thomas Mavrakanas, William Beaubien-Souligny
    Identification, description, and prognostic significance of latent classes based on hemodynamic indicators for patients on maintenance hemodialysis.
  • Suzanne N. Morin, William D.Leslie, Lisa M. Lix
    Effectiveness and Safety of Long-term Antiresorptive Treatment for Osteoporosis in Canada: Improving Shared Decision Making
  • Dan Poenaru, Ariane Marelli
    A voice to the voiceless: Longitudinal patient-reported outcomes, experiences, social determinants of health and health services utilization after major neonatal surgery
  • Alain Ptito
    Imaging biomarkers for early identification of mTBI patients at risk for persistent post-concussive symptoms.
  • Shafaat A. Rabbani
    Role of methyl-CpG-binding domain protein 2 (Mbd2) in breast cancer development, progression and metastasis
  • Jonathan D. Spicer
    Role of the circadian rhythm in the regulation of the tumor microenvironment of non-small cell cancer
  • Donald J. van Meyel
    Dual-function glutamate transporter/chloride channels in brain physiology and neurological diseases.

PRIORITY ANNOUNCEMENTS

HIV/AIDS and STBBI

  • Nadine Kronfli, Frederick L. Altice
    Enhancing uptake of needle and syringe programs in Canadian federal prisons

Learn more on the Canadian Institutes of Health Research (CIHR) website

—Published August 25, 2023

 


 

FALL 2022 CIHR COMPETITION RESULTS

Researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) will embark on 31 new projects designed to accelerate discoveries of benefit to human health, thanks to the Canadian Institutes of Health Research (CIHR) Fall 2022 Project Grants Competition. The RI-MUHC teams received over $16.5 million in project funding.

Across Canada, the competition has approved 382 research grants plus one bridge grant for a total investment of approximately $325 million. In addition, 190 priority announcement grants were funded for a total amount of over $22 million and 12 supplemental prizes were awarded for a total of $375K.

The CIHR Project Grant program is designed to capture ideas with the greatest potential to advance health-related fundamental or applied knowledge, health research, health care, health systems, and/or health outcomes.

“We are extremely proud that RI-MUHC grant recipients and their teams have achieved a 24% success rate this year for CIHR project grants, which is higher than the national level,” says Dr. Rhian Touyz, Executive Director and Chief Scientific Officer, RI‑MUHC. “With the inclusion of priority announcements and bridge grants, we can celebrate the success of 43% of our submissions. This rate testifies to the deep engagement and excellence of the RI-MUHC research community.”

Congratulations to RI-MUHC grant recipients and their teams!
 

PROJECT GRANTS

  • Suhad Ali
    Pharmacological Targeting of Adenosine-to-Inosine (A-to-I) RNA Editing in Aggressive Breast Cancer Subtypes
  • Marcel A. Behr
    Differential virulence within the Mycobacterium tuberculosis complex
  • Nancy E. Braverman, Robert K. Koenekoop, Catherine Argyriou
    Enabling commercialization of retinal gene therapy for Zellweger Spectrum Disorder
  • Deborah M. Da Costa, Steven A. Grover, Elham Rahme, Ilka Lowensteyn, Jane McCusker, Nicole L. Letourneau
    Evaluating Acceptability and Feasibility of an Enhanced Digital Intervention for Preventing Postpartum Mental Health Difficulties in Fathers
  • Deborah M. Da Costa, Elham Rahme, Mary A. De Vera, Evelyne Vinet, Paul R. Fortin
    Mental Health in Individuals with Autoimmune Rheumatic Diseases During the Transition to Parenthood: A Mixed Methods Study to Identify Associated Factors and Support Needs
  • Roy W. Dudley, Myriam Srour, Alain Bouthillier, Alexander G. Weil, Frederic Leblond, Paule Lessard Bonaventure, Maxime Richer, Louis Crevier
    Development of intraoperative label-free Raman Spectroscopy techniques to delineate Focal Cortical Dysplasia borders in Epilepsy surgery and detect cells carrying somatic variants
  • Alex Gregorieff, Sampath K. Loganathan, Danuta Radzioch
    Defining the role of fetal reprogramming in the gut epithelium in health and disease.
  • Marina B. Klein, Lisa Barrett, Brian Conway, Curtis L. Cooper, Pierre Cote, Tammy L. Bourque, John J. Cox, Sahar Z. Saeed, Giada Sebastiani, Michael J. Gill, Shariq Haider, Mark W. Hull, Erica E. Moodie, Valérie Martel-Laferrière, Carrie Martin, Dimitra Panagiotoglou, Neora Pick, Marie-Louise C.Vachon, Sharon L. Walmsley, Alexander C. Wong, James R. Young
    After the Cure: Measuring the full impacts of direct-acting antivirals for people living with HIV/hepatitis C virus coinfection in Canada
  • Richard Kremer, Ioannis Ragoussis, Catalin Mihalcioiu
    Co-targeting parathyroid hormone-related protein (PTHrP) and osteoclast activation to counter breast cancer metastasis to bone.
  • Richard Kremer, Catalin Mihalcioiu
    Anti-parathyroid hormone-related protein (PTHrP) monoclonal antibodies against metastatic cancer
  • Bertrand Lebouché, Kim Engler, Marie-Pascale A. Pomey,Tibor Schuster, Marina B. Klein,Tarek Hijal, David Lessard, John J. Cox, Alexandra de Pokomandy, Nadine Kronfli, Sergio Vicente, Jean-Pierre Routy, Cecilia T. Costiniuk
    Implementation of a patient portal and tailored patient-reported outcome measures to improve health problem detection and retention in HIV care: The DRHIVe Study
  • Jean-Jacques Lebrun, Suhad Ali, Bertrand J. Jean-Claude
    Exploiting a novel dual-specificity cell cycle inhibitor, KP108 as a therapeutic approach for metastatic breast cancer
  • James G. Martin, Maziar Divangahi
    Determinants of susceptibility to influenza infection in pregnant mice Understanding the Mechanistic Basis of Irritant (Chlorine)-Induced Asthma
  • Sushmita Pamidi, Deborah M. Da Costa, Kaberi Dasgupta, Styliani (Stella) Daskalopoulou, Genevieve D. Eastabrook, Nelly Huynh, Richard J. Kimoff, Marie Letourneau, Barbra De Vrijer, Anne-Maude Morency
    Understanding Barriers and Facilitators to the Treatment of Sleep-Disordered Breathing in Pregnancy and Postpartum
  • Yong Rao
    Transsynaptic control of axonal transport in presynaptic assembly and function
  • Erwin A Schurr
    Epigenetic factors affecting the anti-mycobacterial immune response of people living with HIV
  • Benjamin M. Smith, Mohsen Sadatsafavi, Miranda A.Kirby, Andrea Benedetti, Kate M. Johnson, Nicole Ezer
    Improving Canadian Lung Cancer Screening Efficiency with a Computed Tomography Risk Classifier
  • Myriam Srour, Ioannis Ragoussis
    Understanding the genetic architecture and pathophysiology of focal cortical dysplasias using single nucleus RNA sequencing

PRIORITY ANNOUNCEMENTS

Human Development Child and Youth Health - Mid Career Support

  • Geneviève Bernard, David A. Rudko, Guangping Gao
    RNA polymerase III-related leukodystrophy: Understanding disease pathogenesis and developing novel therapeutic approaches using murine models

Institute of Musculoskeletal Health and Arthritis: IMHA Mandate Areas

  • Isabelle Gagnon, Laurie Plotnick, Thierry Pauyo, Ilana Greenstone, Debbie Friedman, Melissa Turner, Ramanakumar Agnihotram, Luc J. Hébert
    Direct access physiotherapy in the Pediatric Emergency Department to improve access to quality care for children and adolescents with musculoskeletal injuries: a randomized control trial

Pediatric Cancer Research

  • Livia Garzia, Nada Jabado
    Epigenetic mechanisms of osteosarcoma pathogenesis and progression.

HIV/AIDS and STBBI

  • Nadine Kronfli, Frederick L. Altice, Mark Stoove, Andrew Lloyd, Lise Lafferty, Behzad Hajarizadeh, Asim Masood
    Enhancing uptake of needle and syringe programs in Canadian federal prisons
  • Nitika Pant Pai, Jorge Luis Martinez, Réjean Thomas, Sahir Bhatnagar
    iSampleSmart!, an innovative, App-facilitated self-sampling screen and treat strategy for common bacterial STIs (Chlamydia trachomatis and Neisseria gonorrhoeae) for Canadian key populations

Epigenetics/epigenomics in human health or disease

  • Shafaat A. Rabbani, Moshe Szyf
    Targeting methyl-CpG-binding domain protein 2 (Mbd2) towards the development of next generation precision Epi-therapies against metastatic breast cancer

Infection and immunology

  • Michael B. Reed, Jesse Shapiro, Nicolas R. Moitessier
    A Genome-Wide Approach for Restoring Antibiotic Susceptibility to Drug-Resistant Mycobacterium tuberculosis.

Patient-Oriented Research: Early-Career Investigator

  • Julio F Fiore Jr, Stephanie M. Wong, Ipshita Prakash, Liane S. Feldman, Justin Rivard, May Lynn Quan, Sarkis H. Meterissian, Emily G. McDonald, Christine Desbiens, Jad Abou Khalil, Lisa Findlay-Shirras, Allison MacIver, Lawrence Lee, Sahir Bhatnagar, Ramanakumar Agnihotram, Marie-Pascale A. Pomey, Janius Tsang, Elaheh Khorasani
    Comparative effectiveness of opioid versus opioid-free post-discharge analgesia after outpatient breast surgery: A randomized controlled trial
  • Shaifali Sandal, Peter Nugus, Marie-Chantal Fortin, Ann Bugeja, Ekaterina Loban, Justin Gill, Antonia Maioni, Rahul Mainra
    System-level approaches to increasing living donor kidney transplantation

BRIDGE GRANTS

  • Moshe Ben-Shoshan, Jennifer L. Protudjer, Kate M. Johnson, Julia Upton, Ran D. Goldman
    PLEDGE: Policies Laws and Emergency Department Guidelines for Epinephrine auto-injector use
  • Moshe Ben-Shoshan, Julia Upton, Derek K. Chu
    SORT: Safety of OIT in a Randomized Trial
  • Christian E. Rocheleau
    Regulation of C. elegans EGFR trafficking and signaling by Rab and Arf GTPases
  • Deborah Assayag, Christopher J. Ryerson, Andrea Benedetti, Julie Morisset
    Sex and gender based disparities in the treatment of patients with interstitial lung diseases

Learn more on the Canadian Institutes of Health Research (CIHR) website

—Published February 20, 2023

 


 

CANADA RESEARCH CHAIRS, SPRING 2022

Tier 1 Canada Research Chairs are awarded to outstanding researchers acknowledged by their peers as world leaders in their fields. Congratulations to three RI-MUHC researchers who earned Tier 1 Chairs in spring 2022! (Competition cycle: 2021-1.)

  • Gabriella Gobbi
    Brain Repair and Integrative Neuroscience Program, RI-MUHC
    Canada Research Chair in Therapeutics for Mental Health, Canadian Institutes of Health Research (CIHR), Tier 1 (New)
  • Madhukar Pai
    Infectious Diseases and Immunity in Global Health Program and Centre for Outcomes Research and Evaluation, RI-MUHC
    Canada Research Chair in Epidemiology and Global Health, CIHR, Tier 1 (Renewal)
  • Cécile Rousseau
    Brain Repair and Integrative Neuroscience (BRaIN) Program, RI-MUHC
    Canada Research Chair in Preventing Violent Radicalization, Social Sciences and Humanities Research Council (SSHRC), Tier 1 (New)

The Canada Research Chairs Program stands at the centre of a national strategy to make Canada one of the world's top countries in research and development. It invests approximately $311 million per year to attract and retain a diverse cadre of world-class researchers, to reinforce academic research and training excellence in Canadian postsecondary institutions.

Learn more about the competition results for McGill University in the McGill Reporter

—Published Jul. 27, 2022

 


 

FRQS SALARY AWARD COMPETITION 2022-2023

Congratulations to researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) who received FRQS salary awards from the Fonds de recherche du Québec – Santé (FRQS)!

Distinguished research scholar

  • Nitika Pant Pai
    Programme de recherche d’implantation global de stratégies numériques innovatrices avec technologies de point de service rapides pour le VIH, les MTS et la COVID-19

Research scholar, Junior 2

  • David Labbé
    Une nutrition de précision pour induire une thérapie par létalité synthétique ciblée grâce à des stratégies d'oncologie personnalisées pour le cancer de la prostate

Research scholars, Junior 1

  • Roberta La Piana
    Leucoencéphalopathies génétiques chez l’adulte et leur chevauchement avec les maladies acquises de la myéline : identification de nouvelles gènopathies par l’intégration de données phénotypiques, d’imagerie avancée et de séquençage de nouvelle génération
  • Julia Valdemarin Burnier
    Suivi des altérations génomiques durant la progression tumorale et métastatique à l'aide de biomarqueurs dérivés de biopsies liquides non-invasives

Clinical research scholars, Senior

  • Moshe Ben-Shoshan
    Allergies aux aliments et aux médicaments: anaphylaxie, taux, causes, gestion et désensibilisation.
  • Alexandra De Pokomandy
    Programme de recherche visant à prévenir ou réduire les conséquences des maladies virales chez les communautés marginalisées
  • Patricia Fontela
    Patients atteints d’infections sévères admis aux soins intensifs : vers une prise en charge optimale fondée sur des données probantes
  • Bertrand Lebouché
    Améliorer l'autogestion et les soins des patients vivant avec le VIH grâce à la santé connectée
  • Meranda Nakhla
    Améliorer les soins de santé et les résultats des enfants et des adolescents atteints de diabète, du diagnostic à la transition vers les soins aux adultes
  • Donald Vinh
    Centre par Excellence pour la Recherche Génétique des Maladies Infectieuses et Immunitaires

Clinical research scholars, Junior 2

  • Natalie Dayan
    Impact des traitements d'infertilité et les issues maternelles sur la santé des femmes à long terme
  • Emily McDonald
    Générer une base de données probantes pour l'optimisation de la gestion sûre et efficace des médicaments
  • Ruth Sapir-Pichhadze
    La médecine de précision au service des greffés

Clinical research scholars, Junior 1

  • Laurence Chapuy
    Plasticité des monocytes humains vers des macrophages réparateurs in vivo et in vitro dans les maladies inflammatoires intestinales
  • Matthew Cheng
    Diminuer la morbidité et la mortalité chez les patients atteints de bactériémies au Canada
  • Roy Dudley
    Méthodes avancées d'imagerie à source magnétique pour la détection et la spectroscopie optique peropératoire pour une résection précise de la zone épileptogène dans l'épilepsie focale pédiatrique.
  • Sinziana Dumitra
    Améliorer les résultats oncologiques chez les patients atteints de sarcome en optimisant l'accès et la qualité des soins
  • Arielle Mendel
    La prévention de dommages médicaux dans les maladies rhumatismales systémiques
  • Shaifali Sandal
    Améliorer l'accès à la transplantation rénale: une approche des systèmes de santé
  • Joshua Vorstenbosch
    Comprendre les interactions dynamiques entre l'hôte et les biomatériaux à l'interface tissu-implant

Intersectorial Audace Progam

  • Jake Barralet
    Visibilité à travers le sang : chirurgie cardiaque mini-invasive sans rayons-X grâce à la robotique intelligente et la vision directe intracardiaque
  • Stella Daskalopoulou
    Trouver ATLANTIS: identification de l'instabilité de la plaque Athérosclérotique à l'aide de techniques d'apprentissage en profondeur

Learn more

—Published June 13, 2022

 


 

FALL 2021 CIHR COMPETITION RESULTS

RI-MUHC teams received $9.5 million in project funding

Researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) will embark on 17 new projects designed to accelerate discoveries of benefit to human health, thanks to the Canadian Institutes of Health Research (CIHR) Fall 2021 Project Grants Competition. The RI-MUHC teams received over $9.5 million in project funding.

Across Canada, the competition has approved 417 research grants plus one bridge grant for a total investment of approximately $325 million. In addition, 105 priority announcement grants were funded for a total amount of over $12 million and 13 supplemental prizes were awarded for a total of $400K.

The CIHR Project Grant program is designed to capture ideas with the greatest potential to advance health-related fundamental or applied knowledge, health research, health care, health systems, and/or health outcomes.

“We are extremely proud of RI-MUHC grant recipients and their teams for rising to the challenges of the year with this resounding success at the national level,” says Dr. Rhian Touyz, Executive Director and Chief Scientific Officer, RI-MUHC. “Their newly funded projects reflect strengths across the biomedical research spectrum and will, beyond a doubt, lead to exciting developments in health care and the knowledge it relies on, for Canadians and for our global neighbours.”

Congratulations to RI-MUHC grant recipients and their teams!

Project Grants

  • Michal Abrahamowicz
    New statistical methods for population-based studies of time-varying drug exposures: development, validation, and real-world analyses of drug safety and effectiveness
  • Faiz Ahmad Khan, Frantz Jean-Louis, Kevin Schwartzman
    Chest Radiography and TB Elimination in Nunavik: novel solutions to fill gaps and strengthen regional capacity
  • Charles Bourque
    Mechanical basis for central dysautonomias following head injury in mice
  • Jun Ding
    Unagi: Computational approach driven repurposed drugs for idiopathic pulmonary fibrosis
  • David Labbé, François Bordeleau
    Protein glycation acts as a substrate-dependent tumorigenic molecular switch in prostate cancer
  • Nathalie Lamarche-Vane
    Investigating the mechanisms underlying the Rac1/Cdc42 GTPase regulator CdGAP in breast cancer
  • Keith Murai
    Astrocyte Nanostructure and Function in the Healthy and Diseased Brain
  • Basil Petrof
    Novel therapies for diaphragm failure in muscular dystrophy
  • Jean-Pierre Routy
    Reversing CMV-induced gut damage to reduce inflammation and improve response to vaccine in people living with HIV
  • Paul Sabatini
    Physiologic- and pathophysiologic-responsive brainstem neurons controlling appetite
  • Rima Slim
    Identify novel genes and mechanisms of molar pregnancies and reproductive failure
  • George Thanassoulis
    Addressing knowledge gaps in the use of lipoprotein testing in cardiovascular prevention

Priority announcements

  • Nathalie Lamarche-Vane
    Netrin-1 receptor "deleted in colorectal cancer" (DCC) signalosome in axonal development
  • Bertrand Lebouché, Kim Engler, Marie-Pascale Pomey, Tibor Schuster
    Implementation of a patient portal and tailored patient-reported outcome measures to improve health problem detection and retention in HIV care: The DRHIVE Study
  • Sara Ahmed, Claudine Auger, Michèle Bleau, Cindy Starnino, Gary Stoopler, Aliki Thomas
    Effectiveness of a customized digital platform to increase coordination of care and uptake of evidence based practices: A stepped-wedge design
  • Jean-Jacques Lebrun
    Defining the role of CDK6 and DNA repair pathways in tumorigenesis and identify CDK4/6-dependent synthetic lethal vulnerabilities in triple negative breast cancer

Priority announcement – Genetics (Bridge Funding: Research Priorities)

  • Sampath Loganathan
    Deciphering the role of metabolic genes in head and neck squamous cell carcinoma

Learn more on the Canadian Institutes of Health Research (CIHR) website

—Published February 10, 2022

 


 

CANADA RESEARCH CHAIRS, 2021 COMPETITIONS

Congratulations to RI-MUHC researchers who received Canada Research Chairs! Fall 2021 competition (2020-2 cycle):

Ahmad Haidar
Canada Research Chair in Artificial Pancreas Systems, CIHR, Tier 2 (renewal)

  • Research focus: developing artificial pancreas systems – medical devices that automatically regulate glucose levels and are considered the most promising therapy for type 1 diabetes.

Dennis Jensen
Canada Research Chair in Clinical Exercise and Respiratory Physiology, CIHR, Tier 2 (renewal)

  • Research focus: advancing knowledge on the mechanisms, measurement and management of activity-related breathlessness and exercise intolerance in people with chronic pulmonary disease.

Ian Watson
Canada Research Chair in Functional Genomics of Melanoma, CIHR, Tier 2 (renewal)

  • Research focus: improving on diagnostic and modalities for cutaneous melanoma, the deadliest form of skin cancer, using computational approaches, in vivo models and biochemical techniques studying patient samples, cell lines and melanoma mouse models.

The Canada Research Chairs Program stands at the centre of a national strategy to make Canada one of the world's top countries in research and development. It invests approximately $295 million per year to attract and retain a diverse cadre of world-class researchers, to reinforce academic research and training excellence in Canadian postsecondary institutions.

Learn more about fall 2021 results for McGill University in the McGill Reporter

—Published Jan. 28, 2022

 


 

FRQS SALARY AWARD COMPETITION 2021-2022

Congratulations to researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) who received FRQS salary awards from the Fonds de recherche du Québec – Santé (FRQS)!

Clinical research scholars

  • Jonathan Afilalo
    Stratégies novatrices d'évaluation et de traitement de la fragilité chez les personnes âgées atteintes d'une maladie cardiaque
  • Faiz Ahmad Khan
    Développement et évaluation d'interventions pour réduire le fardeau et l'impact de la tuberculose sur les populations vulnérables
  • Geneviève Bernard
    Leucodystrophies: Un Programme de Recherche Translationnelle
  • Cecilia Costiniuk
    La perturbation immunitaire chez les personnes vivantes avec le VIH: interactions avec les réservoirs pulmonaires du VIH et cibles possible d'intervention
  • Birgit Frauscher (researcher from The Neuro, affiliated with the RI-MUHC BRaIN Program)
    Simplifier et améliorer l'évaluation préchirurgicale des patients épileptiques
  • Thomas Kitzler
    Une approche systématique pour étudier les relations génotype-phénotype des nouveaux gènes de la maladie rénale.
  • Todd C. Lee
    Exploiter les réseaux d'essais cliniques pour améliorer le traitement des patients atteints de maladies infectieuses importantes
  • Isabelle Malhamé
    Prédiction et prévention de la morbidité cardiovasculaire grave en grossesse
  • Thomas Mavrakanas
    Maladies cardiovasculaires chez le patient avec insuffisance rénale chronique avancée : données prospectives et étude des avancées thérapeutiques récentes
  • Maryam Oskoui
    Données probantes en amyotrophie spinale reposants sur l’analyse de registres
  • Giada Sebastiani
    Profilage des risques et stratégies de dépistage pour lutter contre l'épidémie silencieuse du foie gras non alcoolique
  • Jonathan Spicer
    Au carrefour de l'immunité tumorale innée et adaptative sur la trajectoire de soins des patients atteints d'un cancer pulmonaire opérable: Comment élargir nos créneaux de tirs?
  • John Trakadis
    L’avancement de la génétique clinique psychiatrique, prendre avantage des omiques et l’apprentissage automatique.
  • Pia Wintermark
    Réparer le cerveau des nouveau-nés: Du laboratoire à leur chevet Institut de recherche du Centre universitaire de santé McGill
  • George Zogopoulos
    Accélérer l’oncologie de précision pour les cancers pancréatico-biliaires: un programme partenaire du Consortium québécois contre le cancer

Research scholars

  • Julio Flavio Fiore Junior
    La voie du rétablissement après la chirurgie: Stratégies contemporaines pour mesurer et améliorer les résultats postopératoires.
  • Wei-Hsiang Huang
    Mécanisme et thérapie de l'hyperexcitabilité neurale dans les troubles du spectre autistique
  • Ivan Litvinov
    Élucider la pathogenèse moléculaire, améliorer le diagnostic ainsi que la prise en charge des patients atteints du lymphome cutané à cellules T, mélanome et autres cancers de la peau.
  • Tina Montreuil
    Quantification de l'impact d'interventions préventives et identification de l’impact de symptômes anxieux et dépressifs périnataux sur le développement socioémotionnel de l’enfant
  • Derek Rosenzweig
    Nouvelles approches de délivrance thérapeutique pour une régénération améliorée des tissus musculosquelettiques après resection tumorale, traumatisme ou infection.
  • Jeremy Van Raamsdonk
    Utilisation de la génétique pour comprendre la biologie du vieillissement et de la pathogenèse des maladies neurodégénératives.
  • Bettina Willie
    Causes, détection et traitement des maladies causant des fragilités osseuses

Learn more

—Published May 10, 2021

 


 

FALL 2020 CIHR COMPETITION RESULTS

RI-MUHC teams received $6.9 million in project funding and $2 million more for COVID-19 research

Researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) will embark on 11 new projects designed to accelerate discoveries of benefit to human health, thanks to the Canadian Institutes of Health Research (CIHR) Fall 2020 Project Grants Competition. The RI‑MUHC teams received $6.9 million in project funding.

Across Canada, the competition has approved 354 research grants for a total investment of approximately $274 million. In addition, over $9.5 million was awarded for 97 priority announcement bridge grants and $296K for 11 supplemental prizes.

Exceptionally this year, four RI-MUHC researchers were also awarded operating grants to tackle evidence gaps in COVID-19 research for a total of close to $2 million more in project funding. Across Canada, the CIHR has invested $25.2 million in 52 projects in this stream.

The CIHR Project Grant program is designed to capture ideas with the greatest potential to advance health-related fundamental or applied knowledge, health research, health care, health systems, and/or health outcomes.

Congratulations to RI-MUHC grant recipients and their teams!

Project Grants

  • Jean Bourbeau, Jeffrey R. Brook, Benjamin M. Smith
    Air pollution, climate and COPD: acute and long-term impacts in Canadian populations
  • Matthew P. Cheng, Nick Daneman, Jennie Johnstone, Todd C. Lee
    The S. aureus Network Adaptive Platform Trial (SNAP) Canada: A Randomized Controlled Trial for Penicillin-susceptible, Methicillin-susceptible, and Methicillin-resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients
  • Yen-I Chen, Alan N. Barkun
    Endoscopic ultrasound-guided biliary drainage (EUS-BD) of first intent with a lumen apposing metal stent vs. endoscopic retrograde cholangiopancreatography (ERCP) in the management of patients with malignant distal biliary obstruction: a multi-centre randomized controlled trial (ELEMENT trial)
  • Natalie Dayan, Robert W. Platt
    Beyond survival: examining health of mothers after severe maternal morbidity in Canada (the BEYOND project)
  • Alexandra De Pokomandy
    Creating a learning health system to improve cancer prevention in people living with HIV
  • Maia Kokoeva
    The leptin receptor expressing pericyte links obesity to neuroinflammation
  • Maia Kokoeva
    Could mitotic senescence in NG2-glia explain the remyelination deficit in MS?
  • Jun-Li Liu
    Matricellular protein CCN5/WISP2 mediates a synergistic stimulation of pancreatic beta-cell expansion by IGF-I and Wnt signaling
  • Anie Philip, Andrew C. Leask
    Characterization of a novel anti-fibrotic peptide for the treatment of scleroderma
  • Abhinav Sharma, James M. Brophy, Nandini Dendukuri, Ariane Marelli, Harriette Van Spall
    Identification and prediction of sex-specific cardiovascular causes of death and outcomes in people with diabetes mellitus post myocardial infarction (SCD-DM-MI)

Priority announcements

  • Andrea Benedetti, Brett D. Thombs
    Statistical Methodology for Prediction Modelling to Improve Depression Screening with Individualized Risk Estimates in the Context of Individual Participant Data Meta-analysis

COVID-19 Operating Grants

  • Alan Barkun
    Digestive endoscopy in the era of COVID19: An opportunity for optimizing timely equitable care during the pandemic and beyond
  • Maziar Divangahi
    Developing a novel vaccine against COVID-19
  • Nitika Pant Pai
    Evaluation of a digital, rapid self-sampling strategy for individuals with suspected COVID-19 infection in South Africa and India
  • Cecile Rousseau
    Social polarization and behavioral intentions during the COVID-19 pandemic: A multi-site study of risk and protective factors in Canadian youth

Learn more on the Canadian Institutes of Health Research (CIHR) website

—Published March 19, 2021

 


 

CANADA RESEARCH CHAIRS, 2020 COMPETITIONS

Congratulations to RI-MUHC researchers who received Canada Research Chairs!

Fall 2020 competition (2019-2 cycle):

Spring 2020 competition (2019-1 cycle):

  • Shirin Abbasinejad Enger, Canada Research Chair in Medical Physics, CIHR, Tier 2 (New)
  • Stefanie Blain-Moraes, Canada Research Chair in Biosignal Interaction and Personhood Technology, CIHR, Tier 2 (New)
  • David Buckeridge, Canada Research Chair in Population Health Informatics, CIHR, Tier 1 (New)
  • Nada Jabado, Canada Research Chair in Pediatric Oncology, CIHR, Tier 1 (New)
  • Dick Menzies, Canada Research Chair in Tuberculosis Research, CIHR, Tier 1 (New)

We also congratulate two researchers from The Neuro (Montreal Neurological Institute–Hospital) affiliated with the Brain Repair and Integrative Neuroscience (BRaIN) Program at the RI-MUHC:

  • Boris Bernhardt, Canada Research Chair in Cognitive Neuroinformatics of Healthy and Diseased Brains, CIHR, Tier 2 (New)
  • Robert Zatorre, Canada Research Chair in Auditory Cognitive Neuroscience, CIHR, Tier 1 (New)

The Canada Research Chairs Program stands at the centre of a national strategy to make Canada one of the world's top countries in research and development. It invests approximately $295 million per year to attract and retain a diverse cadre of world-class researchers, to reinforce academic research and training excellence in Canadian postsecondary institutions.

Learn more:
Newswire, Social Sciences and Humanities Research Council of Canada, Dec. 16, 2020
McGill Reporter, fall 2020 results

—Published Aug. 6, 2020; updated Jan. 15, 2021

 


 

FALL 2019 CIHR COMPETITION RESULTS

Researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) will be conducting 25 new projects designed to accelerate discoveries of benefit to human health, thanks to the Canadian Institutes of Health Research (CIHR) Fall 2019 Project Grants Competition. The RI-MUHC teams received over $16 million in project funding.

Across Canada, the competition has approved 385 research grants and 4 bridge grants for a total investment of approximately $275 million. In addition, over $7 million was awarded for 74 priority announcement bridge grants.

The CIHR Project Grant program is designed to capture ideas with the greatest potential to advance health-related fundamental or applied knowledge, health research, health care, health systems, and/or health outcomes.

Congratulations to RI-MUHC grant recipients and their teams!

Project Grants

  • Faiz Ahmad Khan, Glenda Sandy, Christopher Fletcher, Neil Andersson
    Community Health Workers in Tuberculosis Prevention & Care Services in Nunavik
  • Carolyn Baglole, Ilan Azuelos
    Prognostic and Therapeutic Utility of Human Antigen R (HuR) in Fibrosis
  • Swneke Bailey
    Investigating the Molecular Determinants of Peritoneal Metastasis from Gastro-Esophageal Adenocarcinomas
  • Geneviève Bernard
    Unraveling the molecular basis of novel forms of hypomyelinating leukodystrophies
  • Nancy Braverman
    Developing retinal gene augmentation therapy for Zellweger Spectrum Disorder
  • Pnina Brodt
    Regulatory circuits controlling the immune microenvironment of liver metastases
  • Stella Daskalopoulou
    Early Prediction of preeclampsia Using arteriaL Stiffness in high-risk prEgnancies; a multinational study (PULSE)
  • Samuel David
    Ferroptosis-mediated damage in Chronic EAE: implications for Progressive MS
  • Maziar Divangahi
    Targeting the eicosanoid/macrophage axis to enhance host defense against influenza virus infection
  • Maziar Divangahi
    Reprogramming HSCs to generate protective trained immunity against TB
  • Julio Fiore Jr
    Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis
  • Jacques Genest Jr
    Familial Hypercholesterolemia in Canada: Precision and Personalized Approaches to Increase Identification and Improve Clinical outcomes
  • Wassim Kassouf
    Implication of neutrophil extracellular traps in the efficacy of bladder-sparing therapy in muscle invasive bladder cancer
  • Ivan Litvinov
    Ectopic reactivation of normally silenced germ cell programs contributes to genomic instability, carcinogenesis and cancer progression in Cutaneous T-Cell Lymphomas (CTCL).
  • Monzur Murshed
    Understanding the mechanism of vascular elastocalcinosis and its prevention by MGP
  • Basil Petrof
    Understanding the basis of diaphragmatic weakness in critical illness
  • Giada Sebastiani
    The role of fatty liver in the epidemic of advanced chronic liver disease among people living with HIV
  • Elena Torban
    Actin regulation of ciliogenesis: unraveling novel mechanisms of human ciliopathies caused by mutations in the PCP effector genes
  • Simon Wing
    USP19 in metabolism - mechanisms and translation

Priority announcements

  • Stéphanie Chevalier
    A novel multimodal intervention for surgical prehabilitation of patients with lung cancer
  • Andrey Cybulsky
    Defining the role of ER stress in glomerular disease: identification of new therapeutic and diagnostic targets
  • Maia Kokoeva
    Could mitotic exhaustion of NG2-glia explain the remyelination deficit in MS?
  • Ivan Litvinov
    Prize: Early Career Investigator in Cancer
  • Dan Poenaru
    WeChoose: a mixed-methods study for developing a personalized risk communication tool in pediatric surgery
  • Myriam Srour, Dorothy Barthelemy
    The physiological, molecular and genetic mechanisms underlying lateralization of motor control

Learn more on the Canadian Institutes of Health Research (CIHR) website

—Published January 30, 2020