null Mariane Bertagnolli, PhD
angiogenesis • pre-eclampsia • hypertension • cardiac rehabilitation • women's health
My research focuses on elucidating mechanisms that can interrupt the formation of new blood vessels in the mother, placenta and growing fetus in pregnancies that are severely affected by hypertensive disorders such as pre-eclampsia. My laboratory uses a translational approach with murine models and clinical samples to investigate the mechanisms and therapies, including exercise rehabilitation aimed at improving vascularization and, ultimately, preventing disease in women and their children. Research interests include assessing endothelial and microvascular changes in hypertensive pregnancies and investigating the effects of cardiac and obstetric rehabilitation interventions for these patients and their children.
Burchert H, Lapidaire W, Williamson W, McCourt A, Dockerill C, Woodward W, Tan CM, Bertagnolli M, Mohamed A, Alsharqi M, Hanssen H, Huckstep OJ, Leeson P, Lewandowski AJ (2022). Aerobic Exercise Training Response in Preterm-Born Young Adults with Elevated Blood Pressure and Stage 1 Hypertension: A Randomised Controlled Trial. American Journal of Respiratory and Critical Care Medicine. 2022 Dec 2. doi: 10.1164/rccm.202205-0858OC. PMID: 36459100.
Williamson W, Lewandowski AJ, Huckstep OJ, Lapidaire W, Ooms A, Tan C, Mohamed A, Alsharqi M, Bertagnolli M, Woodward W, Dockerill C, McCourt A, Kenworthy Y, Burchert H, Doherty A, Newton J, Hanssen H, Cruickshank JK, McManus R, Holmes J, Ji C, Love S, Frangou E, Everett C, Hillsdon M, Dawes H, Foster C, Leeson P (2022). Effect of moderate to high intensity aerobic exercise on blood pressure in young adults: The TEPHRA open, two-arm, parallel superiority randomized clinical trial. EClinicalMedicine. 48:101445. doi: 10.1016/j.eclinm.2022.101445. PMID: 35706495.
Bertagnolli M, Dartora DR, Lamata P, Zacur E, Mai-Vo TA, He Y, Beauchamp L, Lewandowski AJ, Cloutier A, Sutherland MR, Santos RAS, Nuyt AM (2022). Reshaping the Preterm Heart: Shifting Cardiac Renin-Angiotensin System Towards Cardioprotection in Rats Exposed to Neonatal High-Oxygen Stress. Hypertension. 79(8):1789-1803. doi: 10.1161/HYPERTENSIONAHA.122.19115. PMID: 35588210.
Azinheira Nobrega Cruz N, Stoll D, Casarini DE, Bertagnolli M (2021). Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility. Clinical Science. 135(15):1805-1824. doi: 10.1042/CS20210284. PMID: 34338772.
Tan CMJ, Lewandowski AJ, Williamson W, Huckstep OJ, Yu GZ, Fischer R, Simon JN, Alsharqi M, Mohamed A, Leeson P, Bertagnolli M (2021). Proteomic signature of dysfunctional circulating endothelial colony-forming cells of young adults. Journal of the American Heart Association. e021119. doi: 10.1161/JAHA.121.021119. PMID: 34275329.