null Rhian Touyz, MBBCh, M.Sc. (Med), PhD
hypertension • obesity • cardiovascular risk factors • small vessel disease • vascular biology • oxidative stress • signal transduction • experimental models of human disease
A clinician-scientist, I have dedicated my scientific career to unraveling the mechanisms of hypertension and target organ damage. My research focuses on molecular and vascular mechanisms of hypertension and small vessel disease with a particular interest in vascular signaling and redox biology, vascular biology of cations and TRPM channels, cardiovascular oncology, and cardiometabolic disease, obesity and adipose biology. In research domains ranging from molecular biology to clinical studies, I use a combination of proteomics, cellular and molecular biology, transgenic models, molecular imaging technologies and human physiological assessment. I am committed to translational research, where discovery science translates into clinically impactful outcomes promoting healthy lives and best clinical care for all. My research has been funded by the CIHR, HSFC, JDRF, BHF, ERC, MRC, Wellcome Trust and Leducq Foundation.
Lucas-Herald A, Montezano A, Alves-Lopes R, Haddow L, Alimussina M, O'Toole S, Flett M, Lee B, Amjad S, Steven M, Brooksbank K, McCallum L, Delles C, Padmanabhan S, Ahmed SF, Touyz RM. Vascular dysfunction and increased cardiovascular risk in hypospadias. Eur Heart J. 2022.
Alves-Lopes R, Montezano AC, Neves KB, Harvey A, Rios FJ, Skiba DS, Arendse LB, Guzik TJ, Graham D, Poglitsch M, Sturrock E, Touyz RM. Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension. Hypertension. 2021;78(3):604-616.
Camargo LL, Montezano AC, Hussain M, Wang Y, Zou Z, Rios FJ, Neves KB, Alves-Lopes R, Awan FR, Guzik TJ, Hartley RC, Touyz RM. Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in in human hypertension. Cardiovasc Res. 2021 Jul 28;cvab171.
Neves KB, Morris H, Alves-Lopes R, Muir KW, Moreton F, Delles C, Montezano AC, Touyz RM. Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway. Clin Sci (Lond). 2021;135(6):753-773.
Doehner W, Mazighi M, Hofmann BM, Lautsch D, Hindricks G, Bohula EA, Byrne RA, Camm JA, Casadei B, Caso V, Cognard C,Diener HC, Endres M, Goldstein P, Halliday A, Hopewell JC, Jovanovic DR, Kobayashi A, Kostrubiec M, Krajina A, Landmesser U, Markus HS, Ntaios G, Pezzella FR, Ribo M, Rosano GMC, Rubiera M, Sharma M, Touyz RM, Widimsky P. Cardiovascular care of patients with stroke and high risk of stroke: The need for interdisciplinary action: A consensus report from the European Socrculation. J Hypertens. 2020;38(2):257-265.