tuberculosis • diagnostics • epidemiology • global health • implementation research
My research focuses on tuberculosis. It is a major threat to human health, with 9 million new cases and 1.5 million deaths every year. I have focused my career on improving tuberculosis diagnosis and care, with research that includes evaluating diagnostics tests that could eventually be part of country-level policies, implementation of tools and policies, and improving tuberculosis care for vulnerable populations in different countries worldwide. For example, I have compared the accuracy and usefulness of new tests that can diagnose tuberculosis in a few hours to conventional techniques which may require days before results are known. I am also conducting a study using mystery patients to evaluate the quality of tuberculosis care offered by health providers in India. The overall goal of my research program is to use translational epidemiology and implementation science to support tuberculosis care and control, so that the products developed, knowledge and policies can translate into saved lives.
Pai M, Gokhale K, Joshi RJ, Dogra S, Kalantri SP, Mendiratta DK, Narang P, Daley CL, Granich RM, Mazurek GH, Reingold AL, Riley LW, Colford, JM. Mycobacterium tuberculosis infection in health care workers in rural India: comparison of a whole-blood, interferon-g assay with tuberculin skin testing. JAMA 2005;293:2746-55. PMID: 15941804.
Pai M, Zwerling A, Menzies D. Systematic Review: T-cell Based Assays for the Diagnosis of Latent Tuberculosis Infection-An Update. Ann Intern Med 2008;149:177-184. PMID: 18593687.
Steingart KR, Flores L, Dendukuri N, Schiller I, Laal S, Ramsay A, Hopewell PC, Pai M. Commercial serological tests for the diagnosis of active pulmonary and extrapulmonary tuberculosis: An updated systematic review and meta-analysis. PLoS Med 2011; 8(8): e1001062. PMID: 21857806.
Salje H, Andrews JR, Deo S, Satyanarayana S, Sun AY, Pai M, Dowdy DW. The importance of implementation strategy in scaling up of Xpert MTB/RIF for diagnosis of tuberculosis in the Indian health-care system: a transmission model. PLoS Med 2014;11(7):e1001674. PMID: 25025235.
Alvarez GG, Van Dyk D, Desjardins M, Yasseen A, Aaron SD, Cameron W, Obed N, Baikie M, Pakhale S, Denkinger CM, Sohn H, Pai M. The feasibility, accuracy and impact of Xpert® MTB/RIF testing in a remote Aboriginal community in Canada. Chest 2015 (doi:10.1378/chest.14-2948). PMID: 25789458.