null Madhukar Pai, MD, PhD
tuberculosis • diagnostics • epidemiology • global health • implementation research
My research focuses on tuberculosis (TB), a major threat to human health with 10 million new cases and 1.4 million deaths every year. I have focused my career on improving TB diagnosis and care, with research that includes evaluating and implementing diagnostics tests that could eventually be part of country-level policies, and improving TB care for vulnerable populations. For example, I have compared the accuracy and usefulness of new tests that can diagnose TB in a few hours to conventional techniques which may require days before results are known. I am also conducting studies using mystery patients to evaluate the quality of TB care provided in India and South Africa, and the impact of COVID-19 on TB services. The overall goal of my research program is to use translational epidemiology and implementation science to improve TB care and control, so that the products developed, knowledge and policies can translate into saved lives.
Pai M, Gokhale K, Joshi RJ, Dogra S, Kalantri SP, Mendiratta DK, Narang P, Daley CL, Granich RM, Mazurek GH, Reingold AL, Riley LW, Colford, JM. Mycobacterium tuberculosis infection in health care workers in rural India: comparison of a whole-blood, interferon-g assay with tuberculin skin testing. JAMA 2005;293:2746-55. PMID: 15941804.
Steingart KR, Flores L, Dendukuri N, Schiller I, Laal S, Ramsay A, Hopewell PC, Pai M. Commercial serological tests for the diagnosis of active pulmonary and extrapulmonary tuberculosis: An updated systematic review and meta-analysis. PLoS Med 2011; 8(8): e1001062. PMID: 21857806.
Pai M, Behr MA, Dowdy D, Dheda K, Divangahi M, Boehme CC, Ginsberg A, Swaminathan S, Spigelman M, Getahun H, Menzies D. Tuberculosis. Nature reviews. Disease primers. 2016 Oct 27;2:16076. PMID: 27784885.
Subbaraman R, Nathavitharana RR, Mayer KH, Satyanarayana S, Chadha VK, Arinaminpathy N, Pai M. Constructing care cascades for active tuberculosis: a strategy for program monitoring and identifying gaps in quality of care. PLoS medicine. 2019 Feb 27;16(2):e1002754. PMID: 30811385.
Kwan A, Daniels B, Bergkvist S, Das V, Pai M, Das J. Use of standardised patients for healthcare quality research in low-and middle-income countries. BMJ global health. 2019 Sep 1;4(5):e001669. PMID: 31565413.