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obstructive lung diseases • imaging • cardiopulmonary physiology
My research focuses on investigating the pathophysiological mechanisms of obstructive lung diseases in order to improve clinically meaningful outcomes. Obstructive lung disease (e.g., chronic obstructive pulmonary disease, asthma) represents a leading cause of morbidity and mortality globally, and in Canada. My research integrates methods of population-based epidemiology, state-of-the-art-imaging, and physiology in order to understand disease pathogenesis and expose targetable mechanisms of functional impairment. My specific areas of interest include airway structure and developmental susceptibility to obstructive lung disease; the personalization of obstructive lung disease prevention and treatment based on airway anatomy; and the cardiotoxic effects of breathing mechanics in obstructive lung disease. My clinical and academic interests include improving the quality of lung cancer diagnosis and staging, and medical education.
Smith BM, Kirby M, Hoffman EA, et al. Association of Dysanapsis With Chronic Obstructive Pulmonary Disease Among Older Adults. JAMA. 2020;323(22):2268–2280. doi:10.1001/jama.2020.6918. PMID: 32515814.
Smith BM, Traboulsi H, Austin JHM, Manichaikul A, Hoffman EA, Bleecker ER, Cardoso WV, Cooper C, Couper DJ, Dashnaw SM, Guo J, Han MK, Hansel NN, Hughes EW, Jacobs DR Jr, Kanner RE, Kaufman JD, Kleerup E, Lin CL, Liu K, Lo Cascio CM, Martinez FJ, Nguyen JN, Prince MR, Rennard S, Rich SS, Simon L, Sun Y, Watson KE, Woodruff PG, Baglole CJ, Barr RG; MESA Lung and SPIROMICS investigators. Human airway branch variation and chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E974-E981. doi: 10.1073/pnas.1715564115. Epub 2018 Jan 16. PMID: 29339516.
Smith BM, Hoffman EA, Rabinowitz D, Bleecker E, Christenson S, Couper D, Donohue KM, Han MK, Hansel NN, Kanner RE, Kleerup E, Rennard S, Barr RG. Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax. 2014 Nov;69(11):987-96. doi: 10.1136/thoraxjnl-2014-205160. Epub 2014 Jun 13. PMID: 24928812.
Smith BM, Kawut SM, Bluemke DA, Basner RC, Gomes AS, Hoffman E, Kalhan R, Lima JA, Liu CY, Michos ED, Prince MR, Rabbani L, Rabinowitz D, Shimbo D, Shea S, Barr RG. Pulmonary hyperinflation and left ventricular mass: the Multi-Ethnic Study of Atherosclerosis COPD Study. Circulation. 2013 Apr 9;127(14):1503-11, 1511e1-6. doi: 10.1161/CIRCULATIONAHA.113.001653. Epub 2013 Mar 14. PMID: 23493320.
Smith BM, Austin JH, Newell JD Jr, D'Souza BM, Rozenshtein A, Hoffman EA, Ahmed F, Barr RG. Pulmonary emphysema subtypes on computed tomography: the MESA COPD study. Am J Med. 2014 Jan;127(1):94.e7-23. doi: 10.1016/j.amjmed.2013.09.020. Epub 2013 Oct 9. PMID: 24384106.