null Julia Burnier, PhD
cancer genomics • proteomics • liquid biopsy • ctDNA • metastasis
My research focuses on understanding the dynamic molecular changes that occur during tumour progression and metastasis through liquid biopsy. Our ability to study tumour biology and uncover new approaches to prevent and treat cancer is limited because it relies on tissue from a biopsy, which carries several issues: inadequate sampling, rare but serious complications, and, importantly, the limitation of having one static picture of the tumour – thereby neglecting the dynamics of tumour evolution. To overcome these issues, my lab tracks tumour evolution through a liquid biopsy, a minimally invasive approach to monitor disease progression, recurrence and treatment response using a blood sample. Detection of circulating tumour cells, DNA and extracellular vesicles can contribute to early diagnosis and personalized management. Liquid biopsy can inform on the changing mutational status of the disease and help to guide therapy. My lab works towards identifying specific initiating and metastasis-promoting mutations that can track disease through ctDNA as a biomarker. We also study the contribution of EVs to cancer progression, and synthesize lipid nanoparticles to study EV behaviour and as a drug delivery system for anti-cancer therapy.
Tsering T, Li M, Chen Y, Nadeau A, Laskaris A, Abdouh M, Bustamante P, Burnier JV. EV-ADD, a database for EV-associated DNA in human liquid biopsy samples. J Extracell Vesicles. 2022 Oct;11(10):e12270. doi: 10.1002/jev2.12270. PMID: 36271888.
Ferrier ST, Tsering T, Sadeghi N, Zeitouni A, Burnier JV. Blood and saliva-derived ctDNA is a marker of residual disease after treatment and correlates with recurrence in human papillomavirus-associated head and neck cancer. Cancer Med. 2023 Aug 1. doi: 10.1002/cam4.6191. Epub ahead of print. PMID: 37526056.
Bustamante P, Tsering T, Coblentz J, Mastromonaco C, Abdouh M, Fonseca C, Proença RP, Blanchard N, Dugé CL, Andujar RAS, Youhnovska E, Burnier MN, Callejo SA, Burnier JV. Circulating tumor DNA tracking through driver mutations as a liquid biopsy-based biomarker for uveal melanoma. J Exp Clin Cancer Res. 2021 Jun 16;40(1):196. doi: 10.1186/s13046-021-01984-w. PMID: 34134723.
Tsering T, Laskaris A, Abdouh M, Bustamante P, Parent S, Jin E, Ferrier ST, Arena G, Burnier JV. Uveal Melanoma-Derived Extracellular Vesicles Display Transforming Potential and Carry Protein Cargo Involved in Metastatic Niche Preparation. Cancers (Basel). 2020 Oct 11;12(10):2923. doi: 10.3390/cancers12102923. PMID: 33050649.
Yang SYC, Lheureux S, Karakasis K, Burnier JV, Bruce JP, Clouthier DL, Danesh A, Quevedo R, Dowar M, Hanna Y, Li T, Lu L, Xu W, Clarke BA, Ohashi PS, Shaw PA, Pugh TJ, Oza AM. Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors. Genome Med. 2018 Oct 31;10(1):81. doi: 10.1186/s13073-018-0590-x. PMID: 30382883.