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null Catherine Goudie, MD, FRCPC, M.Sc.

Scientist, RI-MUHC, Glen site

Child Health and Human Development Program

Centre for Outcomes Research and Evaluation

Assistant Professor, Department of Pediatrics, Faculty of Medicine and Health Sciences, McGill University

Department of Pediatrics, Division of Hematology, MUHC

 

Keywords

cancer predisposition syndrome • pediatric • oncology • genetics • decision support tool • eHealth • health economics • health resource allocation • tumor surveillance protocols • second malignancies

Research Focus

My research program focuses on cancer predisposition syndromes that present in childhood. A cancer predisposition syndrome is a genetic condition that increases a person’s risk of developing one or more cancers in their lifetime. Our team has developed an eHealth decision-support tool, called MIPOGG (McGill Interactive Pediatric OncoGenetic Guidelines), that helps doctors recognize their patients with cancer who need to be referred to Genetics because they are at increased risk of having a cancer predisposition syndrome. MIPOGG is an ehealth tool containing 90 tumour-specific algorithms that use clinical, family history and tumour features to generate a recommendation for genetic referral based on the risk of a cancer predisposition syndrome. I am also an associate member of the Department of Human Genetics, the Centre for Genomics and Policy and the Gerald Bronfman Department of Oncology, all affiliated with McGill University.

Selected Publications

Click on Pubmed to see my current publications list

  • C Goudie, M Zawati, B.M Knoppers & A.M Laberge (2024) Genomic sequencing in paediatric oncology: navigating conflicting roles and responsibilities. Journal of Medical Genetics; 62:138-146.

  • C Freycon, P Lupo,L Witkowski, C Budd, W.D Foulkes, C Goudie, (2023). A systematic review of the prevalence of pathogenic or likely pathogenic germline variants in individuals with FOXO1 fusion-positive rhabdomyosarcoma. Pediatr Blood Cancer. 70(4): e30651.

  • R Hebert, N Cullinan, L Armstrong, K.A Blood, J Brossard, L Brunga, C Cacciotti, K Caswell, S Cellot, H Coltin, R.J Deyell, K Felton, C.V Fernandez, A.J Fleming, P Gibson, R Hammad, N Jabado, D.L Johnston, L Lafay-Cousin,… Goudie, C. (2023). Performance of the eHealth decision support tool, MIPOGG, for recognizing children with Li-Fraumeni, DICER1, Constitutional mismatch repair deficiency and Gorlin syndromes. Journal of Medical Genetics, 60: 1218-1223.

  • C Goudie*, L Witkowski, N Cullinan, L Reichman, I Schiller, M Tachdjian, L Armstrong, KA Blood, J Brossard, L Brunga, C Cacciotti, K Caswell, S Cellot, ME Clark, C Clinton, H Coltin, K Felton, CV Fernandez, AJ Fleming, N Fuentes-Bolanos, P Gibson, … , A Villani, & WD Foulkes. Performance of the McGill Interactive Pediatric OncoGenetic Guidelines for Identifying Cancer Predisposition Syndromes. JAMA Oncol. 2021; 7; (12):1806-1814.

  • N Cullinan, I Schiller, G Di Giuseppe, M Mamun, L Reichman, C Cacciotti, L Wheaton, K Caswell, B Di Monte, P Gibson, D L Johnston, A Fleming, J Pole, D Malkin, W Foulkes, N Dendukuri, C Goudie, P Nathan. Utility of a Cancer Predisposition Screening Tool for Predicting Subsequent Malignant Neoplasms in Childhood Cancer Survivors. J Clin Oncol. 39, 3207-3216 (2021).