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skeletal mechanobiology • bone adaptation • bone regeneration
My research focuses on understanding how the mechanical environment influences bone adaptation and regeneration during growth, skeletal maturation, and aging. Specifically, I am investigating the regulation of modeling and remodeling processes by mechanical loading and the role of osteoblastic cells (osteoblasts and osteocytes, the primary sensor and effector cells of mechanical cues) in mechano-sensation processes. My research involves in vitro, in silico, and preclinical in vivo models as well as clinical trials to investigate the mechanism(s) responsible for the skeletal response to mechanical stimuli.
Willie BM, Zimmermann E, Vitienes I, Main RP, Komarova SV, Bone adaptation: safety factors and load predictability in shaping skeletal form, Bone, 21;131:115114, 2020.
Main RP, Shefelbine SJ, Meakin LB, Silva MJ, van der Meulen MCH, Willie BM, The murine axial compression tibial loading model to study bone mechanobiology: Implementing the model and reporting results. Journal of Orthopedic Research, Sep 11. doi: 10.1002/jor.24466.
Kruck B, Zimmermann EA, Damerow S, Figge C, Julien C, Wulstein D, Thiele T, Martin M, Hamdy R, Reumann MK, Duda GN, Checa S, Willie BM, Sclerostin-neutralizing antibody treatment enhances bone formation but does not rescue delayed healing due to mechanical instability, Journal of Bone and Mineral Research, 33(9):1686-1697, 2018.
Mikolajewicz N, Zimmerman E, Willie BM, Svetlana V. Komarova S, Mechanically-evoked ATP release is regulated by facilitated membrane resealing in murine osteoblasts, E-life, Oct 16;7, 2018.
Yang H, Albiol L, Chan WL, Seliger A, Wulsten D, Thelen M, Thiele T, Spevak M, Boskey A, Kornak U, Checa S, Willie BM, Examining tissue composition, whole-bone morphology and mechanical behavior of GorabPrx1 mice tibiae: a mouse model of premature aging, Journal of Biomechanics, 65, 145–153, 2017.