null Jeremy Van Raamsdonk, PhD, M.Sc
aging • neurodegeneration • Parkinson's disease • Huntington's disease • mitochondria • animal models • C. elegans • stress resistance • oxidative stress • reactive oxygen species
I use a genetic approach to study the biology of aging and the causative factors involved in neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. My work aims to understand the molecular mechanisms underlying the aging process, and to use the knowledge gained to promote healthy aging and to develop new treatments for neurodegenerative disorders.
Mild mitochondrial impairment enhances innate immunity and longevity through ATFS-1 and p38 signaling. Campos JC, Wu Z, Rudich PD, Soo SK, Mistry M, Ferreira JC, Blackwell TK, Van Raamsdonk JM. EMBO Rep. 2021 Oct 7:e52964. doi: 10.15252/embr.202152964. Online ahead of print. PMID: 34617666.
Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors. Soo SK, Traa A, Rudich PD, Mistry M, Van Raamsdonk JM. Life Sci Alliance. 2021 Sep 28;4(12):e202101182. doi: 10.26508/lsa.202101182. Print 2021 Dec. PMID: 34583931.
Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease. Senchuk MM, Van Raamsdonk JM, Moore DJ. Neurobiol Dis. 2021 Apr;151:105267. doi: 10.1016/j.nbd.2021.105267. Epub 2021 Jan 12. PMID: 33450392.
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies. Shields HJ, Traa A, Van Raamsdonk JM. Front Cell Dev Biol. 2021 Feb 11;9:628157. doi: 10.3389/fcell.2021.628157. eCollection 2021. PMID: 33644065.
Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders. Soo SK, Rudich PD, Traa A, Harris-Gauthier N, Shields HJ, Van Raamsdonk JM. Mech Ageing Dev. 2020 Sep;190:111297. doi: 10.1016/j.mad.2020.111297. Epub 2020 Jun 28. PMID: 32610099.