null Jean-Pierre Routy, MD, FRCPC

Senior Scientist, RI-MUHC, Glen site

Infectious Diseases and Immunity in Global Health Program

Centre for Translational Biology

Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

Department of Medicine, Division of Hematology, MUHC



HIV • chronic viral infections • CMV • HHV8 • HIV reservoirs • gut

Research Focus

My research focuses on human immunodeficiency virus (HIV) pathogenesis aiming at finding an HIV cure. Improving knowledge in immune tolerance in cancer and immunometabolism will be key to developing strategy to conquer cancers and auto-immune diseases.

Selected Publications

Click on Pubmed to see my current publications list

  • Cytomegalovirus Seropositivity Is Associated With Increased Microbial Translocation in People Living With Human Immunodeficiency Virus and Uninfected Controls. Ramendra R, Isnard S, Lin J, Fombuena B, Ouyang J, Mehraj V, Zhang Y, Finkelman M, Costiniuk C, Lebouché B, Chartrand-Lefebvre C, Durand M, Tremblay C, Ancuta P, Boivin G, Routy JP. Clin Infect Dis. 2020 Sep 12;71(6):1438-1446. doi: 10.1093/cid/ciz1001. PMID: 31608409.

  • Circulating (1→3)-β-D-glucan Is Associated With Immune Activation During Human Immunodeficiency Virus Infection. Mehraj V, Ramendra R, Isnard S, Dupuy FP, Ponte R, Chen J, Kema I, Jenabian MA, Costinuik CT, Lebouché B, Thomas R, Coté P, Leblanc R, Baril JG, Durand M, Chartrand-Lefebvre C, Tremblay C, Ancuta P, Bernard NF, Sheppard DC, Routy JP; Montreal Primary HIV Infection Study and Canadian HIV and Aging Cohort Study Groups. Clin Infect Dis. 2020 Jan 2;70(2):232-241. doi: 10.1093/cid/ciz212. PMID: 30877304.

  • Therapeutic Perspectives in the Systemic Treatment of Kaposi's Sarcoma. Valantin MA, Royston L, Hentzien M, Jary A, Makinson A, Veyri M, Ronot-Bregigeon S, Isnard S, Palich R, Routy JP. Cancers (Basel). 2022 Jan 18;14(3):484. doi: 10.3390/cancers14030484. PMID: 35158752.

  • Repurposing Metformin in Nondiabetic People With HIV: Influence on Weight and Gut Microbiota. Isnard S, Lin J, Fombuena B, Ouyang J, Varin TV, Richard C, Marette A, Ramendra R, Planas D, Raymond Marchand L, Messaoudene M, Van der Ley CP, Kema IP, Sohail Ahmed D, Zhang Y, Finkelman M, Routy B, Angel J, Ancuta P, Routy JP. Open Forum Infect Dis. 2020 Sep 11;7(9):ofaa338. doi: 10.1093/ofid/ofaa338. eCollection 2020 Sep. PMID: 32964062.

  • LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy. Planas D, Pagliuzza A, Ponte R, Fert A, Marchand LR, Massanella M, Gosselin A, Mehraj V, Dupuy FP, Isnard S, Goulet JP, Lesage S, Cohen EA, Ghali MP, Angel JB, Chomont N, Routy JP, Ancuta P. EBioMedicine. 2021 Mar;65:103270. doi: 10.1016/j.ebiom.2021.103270. Epub 2021 Mar 1. PMID: 33662832.