null Pia Wintermark, MD

Scientist, RI-MUHC, Glen site

Child Health and Human Development Program

Centre for Translational Biology

Associate Professor, Department of Pediatrics, Faculty of Medicine and Health Sciences, McGill University

Department of Pediatrics, Division of Neonatology, MUHC



brain • imaging • newborn • repair

Research Focus

My research focuses on the understanding of the causes and consequences of brain damage in sick babies. The main goal of my lab is to improve the clinical care of sick babies in the neonatal intensive care unit and to develop innovative strategies to prevent or repair brain damage, and thus to improve the future of these babies. My laboratory is translational, with both bench and bedside components. More specifically, I am studying the unique profile of brain damage in human newborns, using advanced neuroimaging techniques and bedside monitoring, in order to identify as early as possible the babies who will develop brain damage. In parallel, I am also using a lab model of neonatal brain damage to test innovative treatments to prevent or repair brain damage. By combining these approaches, my lab has thus the potential to develop new treatments that could reduce brain damage in sick babies who will need it the most. We are now testing one of this treatment to repair brain damage in babies.

Selected Publications

Click on Pubmed to see my current publications list

  • Wintermark P, Lapointe A, Steinhorn R, Rampakakis E, Burhenne J, Meid AD, Bajraktari-Sylejmani G, Khairy M, Altit G, Adamo MT, Poccia A, Gilbert G, Saint-Martin C, Toffoli D, Vachon J, Hailu E, Colin P, Haefeli WE. Feasibility and Safety of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia (SANE-01): A Randomized, Double-blind, Placebo-controlled Phase Ib Clinical Trial. J Pediatr. 2024 Mar;266:113879. doi: 10.1016/j.jpeds.2023.113879. Epub 2023 Dec 22. PMID: 38142044.

  • Wintermark P, Mohammad K, Bonifacio SL; Newborn Brain Society Guidelines and Publications Committee. Electronic address: Proposing a care practice bundle for neonatal encephalopathy during therapeutic hypothermia. Semin Fetal Neonatal Med. 2021 Oct;26(5):101303. doi: 10.1016/j.siny.2021.101303. Epub 2021 Oct 16. PMID: 34711527.

  • Yazdani A, Howidi B, Shi MZ, Tugarinov N, Khoja Z, Wintermark P. Sildenafil improves hippocampal brain injuries and restores neuronal development after neonatal hypoxia-ischemia in male rat pups. Sci Rep. 2021 Nov 11;11(1):22046. doi: 10.1038/s41598-021-01097-6. PMID: 34764335.

  • Al Amrani F, Kwan S, Gilbert G, Saint-Martin C, Shevell M, Wintermark P. Early Imaging and Adverse Neurodevelopmental Outcome in Asphyxiated Newborns Treated With Hypothermia. Pediatr Neurol. 2017 Aug;73:20-27. doi: 10.1016/j.pediatrneurol.2017.04.025. Epub 2017 May 19. PMID: 28619376.

  • Boudes E, Tan X, Saint-Martin C, Shevell M, Wintermark P. MRI obtained during versus after hypothermia in asphyxiated newborns. Arch Dis Child Fetal Neonatal Ed. 2015 May;100(3):F238-42. doi: 10.1136/archdischild-2014-306550. Epub 2015 Jan 20. PMID: 25605620.