brain • imaging • newborn • retina • repair
My research focuses on the understanding of the causes and consequences of brain and eyes damages in sick babies. More specifically, we are studying the unique profile of brain and eyes damages in human newborns, using advanced neuroimaging techniques and bedside monitoring, as well as detailed examination of the placentas of these children, in order to identify as early as possible the babies who will develop later brain and eye damage. In parallel, we are also using a lab model of neonatal brain damage to develop treatments to prevent or repair these brain and eyes damages. By combining these approaches, the lab has thus the potential to develop new treatments that could lead to decrease brain and eyes damages in sick babies who will need it the most. With doing so, we are hoping to improve the clinical care of sick babies in the neonatal intensive care unit and their future outcome.
Boudes E, Tan X, Saint-Martin C, Shevell M, Wintermark P. Magnetic resonance imaging obtained during versus after hypothermia in asphyxiated Newborns. Arch Dis Child Fetal Neonatal Ed. 2015 [Epub ahead of print]. PMID: 25605620.
Peng S, Boudes E, Tan X, Saint-Martin C, Shevell M, Wintermark P. Does near-Infrared spectroscopy identify asphyxiated newborns at risk of developing brain injury during hypothermia treatment? Am J Perinatol. 2015 [Epub ahead of print]. PMID: 25594221.
Wintermark P, Hansen A, Gregas MC, Soul J, Labrecque M, Robertson RL, Warfield SK. Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia. AJNR Am J Neuroradiol. 2011; 32(11):2023-2029. PMID: 21979494.
Wintermark P, Boyd T, Gregas MC, Labrecque M, Hansen A. Placental pathology in asphyxiated newborns meeting the criteria for therapeutic hypothermia. Am J Obstet Gynecol. 2010;203(6):579.e1-9. PMID: 20851370.
Wintermark P, Lechpammer M, Warfield SK, Kosaras B, Takeoka M, Poduri A, Madsen JR, Bergin AM, Whalen S, Jensen FE. Perfusion imaging of focal cortical dysplasia using arterial spin labeling: correlation with histopathological vascular density. J Child Neurol. 2013;28(11):1474-1482 PMID: 23696629.