null Jonathan Spicer, BSc (Hon), MD, PhD, FRCS
lung cancer • neoadjuvant • immunotherapy • neutrophil • surgery
My research focuses on the continuum of care for patients with lung cancer. Our lab studies the interplay between the innate and adaptive immune system during lung cancer progression and in response to conventional and novel therapeutics. In particular, our lab has expertise in the biology of neutrophil extracellular traps during cancer progression and in response to therapy. From clinical and translational perspectives, I lead one of the world's most active programs in neoadjuvant therapy for patients with operable lung cancer and leverage this clinical activity for correlative science designed to understand metrics of response and failure to emerging treatments.
Cools-Lartigue J, Spicer J, McDonald B, Gowing S, Chow S, Giannias B, Bourdeau F, Kubes P, Ferri L. Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Invest. 2013 Jul 1;123(8):3446–58. doi: 10.1172/JCI67484. Epub ahead of print. PMID: 23863628.
Spicer JD, McDonald B, Cools-Lartigue JJ, Chow SC, Giannias B, Kubes P, Ferri LE. Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells. Cancer Res. 2012 Aug 15;72(16):3919-27. doi: 10.1158/0008-5472.CAN-11-2393. Epub 2012 Jul 2. PMID: 22751466.
Rayes RF, Mouhanna JG, Nicolau I, Bourdeau F, Giannias B, Rousseau S, Quail D, Walsh L, Sangwan V, Bertos N, Cools-Lartigue J, Ferri LE, Spicer JD. Primary tumors induce neutrophil extracellular traps with targetable metastasis promoting effects. JCI Insight. 2019 Jul 25;5(16):e128008. doi: 10.1172/jci.insight.128008. PMID: 31343990.
Surgical outcomes from the phase 3 CheckMate 816 trial: Nivolumab (NIVO) + platinum-doublet chemotherapy (chemo) vs chemo alone as neoadjuvant treatment for patients with resectable non-small cell lung cancer (NSCLC). Jonathan Spicer, Changli Wang, Fumihiro Tanaka, Gene Brian Saylors, Ke-Neng Chen, Moishe Liberman, Everett E. Vokes, Nicolas Girard, Shun Lu, Mariano Provencio, Tetsuya Mitsudomi, Mark M. Awad, Enriqueta Felip, Patrick M. Forde, Scott Swanson, Julie R. Brahmer, Keith Kerr, Cécile Dorange, Junliang Cai, and Stephen Broderick. Journal of Clinical Oncology 2021 39:15_suppl, 8503-8503.
Shinde-Jadhav, S., Mansure, J.J., Rayes, R.F. et al. Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer. Nat Commun 12, 2776 (2021). https://doi.org/10.1038/s41467-021-23086-z.