chronic obstructive pulmonary disease • toxicology • cigarette smoke • inflammation • lungs
My research focuses on chronic obstructive pulmonary disease and cigarette smoke-induced lung diseases. Chronic and persistent inflammation and the death of lung cells are involved in the etiology of lung diseases such as chronic obstructive pulmonary disease (COPD), which is almost always caused by cigarette smoke. There is no cure for individuals afflicted with COPD and there are no effective therapies that can reduce disease progression. My laboratory's research aims to understand which intracellular pathways control cigarette smoke-induced inflammation and cell death. Utilizing cell-based as well as animal models of cigarette smoke exposure, in conjunction with biochemical, molecular and genetic techniques, my lab is currently investigating the role of the aryl hydrocarbon receptor (AhR) as a novel attenuator of smoke-induced lung damage.
Sheridan JA, Zago M, Nair P, Li PZ, Bourbeau J, Tan WC, Hamid Q, Eidelman DH, Benedetti AL, Baglole CJ. Decreased expression of the NF-κB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression. Respir Res. 2015 May 6;16:54. doi: 10.1186/s12931-015-0214-6. PMID: 25943190.
Labonté L, Coulombe P, Zago M, Bourbeau J, Baglole CJ. Alterations in the expression of the NF-κB family member RelB as a novel marker of cardiovascular outcomes during acute exacerbations of chronic obstructive pulmonary disease. PLoS One. 2014 Nov 19;9(11):e112965. doi: 10.1371/journal.pone.0112965. eCollection 2014. PMID: 25409035.
Hecht E, Zago M, Sarill M, Rico de Souza A, Gomez A, Matthews J, Hamid Q, Eidelman DH, Baglole CJ. Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):511-25. doi: 10.1016/j.taap.2014.08.023. Epub 2014 Aug 30. PMID: 25178717.
de Souza AR, Zago M, Eidelman DH, Hamid Q, Baglole CJ. Aryl hydrocarbon receptor (AhR) attenuation of subchronic cigarette smoke-induced pulmonary neutrophilia is associated with retention of nuclear RelB and suppression of intercellular adhesion molecule-1 (ICAM-1). Toxicol Sci. 2014 Jul;140(1):204-23. doi: 10.1093/toxsci/kfu068. Epub 2014 Apr 20. PMID: 24752502.
Zago M, Sheridan JA, Nair P, Rico de Souza A, Gallouzi IE, Rousseau S, Di Marco S, Hamid Q, Eidelman DH, Baglole CJ. Aryl hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding. PLoS One. 2013 Sep 27;8(9):e74953. doi: 10.1371/journal.pone.0074953. eCollection 2013. PMID: 24086407.