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chronic obstructive pulmonary disease • toxicology • cigarette smoke • inflammation • lungs
My research program consists of three overlapping themes centred on inhalation toxicology and respiratory disease respiratory disease pathogenesis. These themes are tobacco, cannabis and pulmonary fibrosis.
Tobacco smoke causes many lung diseases, and there is now a surge in the use of e-cigarettes, where the long-term health effects are unknown. Therefore, we use preclinical models of tobacco and e-cigarette exposure to understand the pathogenesis of respiratory disease.
Cannabis is mostly consumed via inhalation, but the safety and efficacy of cannabis products are largely unknown. We have established a preclinical pipeline to test inhaled cannabis, cannabinoids and novel drugs in various preclinical disease models.
Pulmonary fibrosis causes the lungs to become scarred, leading to death from respiratory failure. Risk factors for pulmonary fibrosis include cigarette smoke. There is no cure for pulmonary fibrosis and treatment options are few. Therefore, we seek to identify novel cellular pathways that can be used as therapeutic targets against fibrotic disease.
Inhalation Toxicology of Vaping Products and Implications for Pulmonary Health. Traboulsi H, Cherian M, Abou Rjeili M, Preteroti M, Bourbeau J, Smith BM, Eidelman DH, Baglole CJ.Int J Mol Sci. 2020 May 15;21(10):E3495. doi: 10.3390/ijms21103495. PMID: 32429092.
Pulmonary neutrophilia caused by absence of the NF-κB member RelB is dampened by exposure to cigarette smoke. Pareek S, Traboulsi H, Allard B, Rico de Souza A, Eidelman DH, Baglole CJ.Mol Immunol. 2019 Oct;114:395-409. doi: 10.1016/j.molimm.2019.08.011. Epub 2019 Aug 30. PMID: 31476634.
The Aryl Hydrocarbon Receptor and the Maintenance of Lung Health. Guerrina N, Traboulsi H, Eidelman DH, Baglole CJ.Int J Mol Sci. 2018 Dec 5;19(12):3882. doi: 10.3390/ijms19123882. Free PMC article. Review. PMID: 30563036.
Human airway branch variation and chronic obstructive pulmonary disease. Smith BM, Traboulsi H, Austin JHM, Manichaikul A, Hoffman EA, Bleecker ER, Cardoso WV, Cooper C, Couper DJ, Dashnaw SM, Guo J, Han MK, Hansel NN, Hughes EW, Jacobs DR Jr, Kanner RE, Kaufman JD, Kleerup E, Lin CL, Liu K, Lo Cascio CM, Martinez FJ, Nguyen JN, Prince MR, Rennard S, Rich SS, Simon L, Sun Y, Watson KE, Woodruff PG, Baglole CJ, Barr RG; MESA Lung and SPIROMICS investigators.Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E974-E981. doi: 10.1073/pnas.1715564115. Epub 2018 Jan 16. Free PMC article. Clinical Trial. PMID: 29339516.
RelB attenuates cigarette smoke extract-induced apoptosis in association with transcriptional regulation of the aryl hydrocarbon receptor. Iu M, Zago M, Rico de Souza A, Bouttier M, Pareek S, White JH, Hamid Q, Eidelman DH, Baglole CJ.Free Radic Biol Med. 2017 Jul;108:19-31. doi: 10.1016/j.freeradbiomed.2017.02.045. Epub 2017 Feb 27. PMID: 28254546.