Breadcrumb

null Laurence Chapuy, MD, PhD

Keywords


inflammatory bowel disease • mucosal immunology • innate immunity • mononuclear phagocytes • fibrosis

Research Focus


My research focuses on immunological mechanisms underlying inflammatory bowel diseases. I study the role of innate immune cells, called mononuclear phagocytes, in the inflammatory and scar tissues of patients with Crohn's disease and ulcerative colitis.

Selected Publications


Click on Pubmed to see my current publications list

  • Chapuy, L., Bsat, M., Sarkizova, S., Rubio, M., Therrien, A., Wassef, E., Bouin, M., Orlicka, K., Weber, A., Hacohen, N., Villani, A.C., Sarfati, M. Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's disease. Mucosal Immunol, 12(3):703-719. PMID: 30670762.

  • Chapuy, L., Bsat, M., Rubio, M., Harvey, F., Motta, V., Schwenter, F., Wassef, R., Richard, C., Deslandres, C., Nguyen, B.N., Soucy, G., Hacohen, N., Fritz, J., Villani, A.C., Mehta, H., Sarfati, M. Transcriptomic analysis and high dimensional phenotypic mapping of mononuclear phagocytes in mesenteric lymph nodes reveal differences between ulcerative colitis and Crohn's disease. Journal of Crohn and colitis, 13;14(3):393-405. PMID: 31541232.

  • Chapuy, L., Bsat, M., Rubio, M., Sarkizova, S., Therrien, A., Bouin, M., Orlicka, K., Weber, A., Soucy, G., Villani, A.C., Sarfati, M. IL-12 and mucosal CD14+ monocyte-like cells induce IL-8 in colonic memory CD4+ T cells of patients with Ulcerative colitis but not Crohn's disease. Journal of Crohn and Colitis, 14(1):79-95. PMID: 31206576.

  • Chapuy, L., Bsat, M., Mehta, H., Rubio, M., Wakahara, K., Van, V.Q., Baba, N., Cheong, C., Yun, T.J., Panzini, B., Wassef, R., Richard, C., Tamaz, R., Soucy, G., Delespesse, G., Sarfati, M. Basophils increase in Crohn's disease and Ulcerative colitis and favor mesenteric lymph node memory Th17/Th1 response. J Allergy Clin Immunol, 134(4):978-81.e1. PMID: 24996262.

  • Bsat, M., Chapuy, L., Rubio, M., and Sarfati, M. A two-step human culture system replicates intestinal monocyte maturation cascade: Conversion of tissue-like inflammatory monocytes into macrophages. Eur J Immunol, 50(1):1676-1690. PMID: 32557554.