null Gabriella Gobbi, MD, PhD
cannabis • cannabinoids • endocannabinoid system • THC • CBD • cannabidiol • melatonin • MT1 receptor • MT2 receptor • sleep • depression • mood disorders • pain • psychedelics • LSD • psilocybin
My research approach spans from bench to bedside, bridging the gaps between fundamental and clinical research. My lab is interested in understanding the pathophysiology of mental diseases and over the years has discovered new treatments and cures for them. We have demonstrated in animal models and in humans that the long-term use of cannabis in adolescence can lead to depression later in life. We have also discovered and patented novel selective agonists of the melatonin MT1 and MT2 receptors for treating pain, insomnia, and anxiety. Recently, we published and patented research unveiling the mechanism of action of LSD and psychedelics in social anxiety and post-stress anxiety.
De Gregorio, D., Inserra, A., Enns, J.P., Markopoulos, A., Pileggi, M., El Rahimy, Y., Lopez-Canul, M., Comai, S. and Gobbi, G., 2022. Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline. Neuropsychopharmacology, 2022,1-11. PMID: 35301424.
De Gregorio D., Popic E., Enns J., Inserra A., Skalecka A., Markopoulos A., Posa L., Lopez-Canul M., Qianzi H., Lafferty C, Britt J., Comai S., Ahuilar-Valles A., Sonenberg N., Gobbi G. Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. Proceeding of National Academy of Sciences of the USA. 2021 118.5. PMID: 33495318.
Gobbi G., Comai S. Differential function of Melatonin MT1 and MT2 receptors in REM and NREM sleep. Frontiers in Endocrinology, 2019 10:87. PMID: 30881340.
Gobbi G. Atkin T, Zytynski, T; Wang S, Askari S., Boruff J., Ware M., Marmorstein N., Cipriani A., Dendukuri, N., Mayo N., Cannabis use in adolescence and risk of depression in young adulthood: A systematic review and meta-analysis. JAMA Psychiatry, Feb 13, 2019. PMID: 30758486.
Moderie, C., Nuñez, N., Comai, S., Saint-Laurent, M., Fielding, A., Low, N., & Gobbi, G. (2022). Distinct Effects of Antidepressants in Association With Mood Stabilizers and/or Antipsychotics in Unipolar and Bipolar Depression. Journal of Clinical Psychopharmacology, 42(2), 118-124. PMID: 35067518.