Daniel Dufort, PhD - Research Institute of the McGill University Health Centre
Embryo implantation • placenta • preterm birth • embryo-uterine crosstalk • uterine development
My research focuses on elucidating the embryo-uterine communication that is required for successful implantation of the embryo. We are using molecular, embryological, and genetic approaches to identify the signaling pathways and their roles in the implantation process. We are also interested in elucidating the role of maternal signals in proper development and function of the placenta which are often associated with complications during pregnancy such as preeclampsia and preterm birth.
Starr., L.M., Heba, T., and D. Dufort 2018. Evidence of a gene-environment interaction of NODAL variants and infection in preterm birth. J Perinatol. 2018 Feb 16. doi: 10.1038.
Omar Farah, Steffen Bichelle, Janet Rossant and Daniel Dufort. 2017. Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility. Biol Reprod. 2017 Nov 1;97(5):688-697. doi: 10.1093.
Omar Farah, Steffen Bichelle, Janet Rossant and Daniel Dufort.. 2017. Regulation of Porcupine-dependent Wnt signaling is essential for uterine development and function. Reproduction. 2018 Jan;155(1):93-102. doi: 10.153.
Hari Krishna Thulluru, Craig Park, Daniel Dufort, Gunilla Kleiverda, Cees Oudejans, Marie van Dijk. 2013. Maternal Nodal inversely affects NODAL and STOX1 expression in the fetal placenta. Front Genet. 2013 Aug 27;4:170.
Craig B Park, Francesco J Demayo, John P Lydon, and Daniel Dufort. 2012. Nodal in the Uterus Is Necessary for Proper Placental Development and Maintenance of Pregnancy. Biol Reprod. Jun 28;86(6):194. doi: 10.1095.