fatty liver • serum fibrosis biomarkers • hepatitis B • hepatitis C • HIV
My research focuses on screening for liver disease and fatty liver of at risk populations, including HIV+ patients, patients with inflammatory bowel disease, liver transplant recipients. To conduct these studies, I employ a non-invasive machine, which is ultrasound based, named Fibroscan. Moreover, I am conducting interventional trials to reduce the fatty liver by vitamin E and switch to less hepatotoxic drugs.
Serum fibrosis biomarkers predict death and graft loss in liver transplant recipients. Bhat M, Ghali P, Rollet-Kurhajec KC, Bhat A, Wong P, Deschenes M, Sebastiani G. Liver Transpl. 2015 Jul 20. doi: 10.1002/lt.24217. [Epub ahead of print] PMID: 26194602.
Prognostic Value of Non-Invasive Fibrosis and Steatosis Tools, Hepatic Venous Pressure Gradient (HVPG) and Histology in Nonalcoholic Steatohepatitis.Sebastiani G, Alshaalan R, Wong P, Rubino M, Salman A, Metrakos P, Deschenes M, Ghali P. PLoS One. 2015 Jun 17;10(6):e0128774. doi: 10.1371/journal.pone.0128774. eCollection 2015. PMID: 26083565.
Incidence and predictors of hepatic steatosis and fibrosis by serum biomarkers in a large cohort of human immunodeficiency virus mono-infected patients. Sebastiani G, Rollet-Kurhajec KC, Pexos C, Gilmore N, Klein MB. Open Forum Infect Dis. 2015 Feb 23;2(1):ofv015. doi: 10.1093/ofid/ofv015. eCollection 2015 Jan. PMID: 26034765.
Occult cirrhosis diagnosed by transient elastography is a frequent and under-monitored clinical entity. Chen T, Wong R, Wong P, Rollet-Kurhajec KC, Alshaalan R, Deschenes M, Ghali P, Sebastiani G. Liver Int. 2015 Feb 9. doi: 10.1111/liv.12802. [Epub ahead of print] PMID: 25676459.
Pegylated interferon-associated retinopathy is frequent in hepatitis C virus patients with hypertension and justifies ophthalmologic screening. Vujosevic S, Tempesta D, Noventa F, Midena E, Sebastiani G. Hepatology. 2012 Aug;56(2):455-63. doi: 10.1002/hep.25654. Epub 2012 Jun 11. PMID: 22331668.