HIV • HIV reservoirs • chronic lung disease • pulmonary inflammation • pulmonary immunity
My research focuses on potential factors associated with accelerated chronic lung disease in HIV infection. Despite the success of highly active antiretroviral therapy (HAART), individuals with HIV appear to be at increased risk of chronic lung disease which cannot be accounted for by smoking alone. I am interested in the role of the lungs as reservoirs of HIV infection, in addition to the effect of pulmonary inflammation on the size of the lung HIV reservoir in individuals on effective HAART. I am also interested in pulmonary immune abnormalities in the context of HIV infection.
Costiniuk CT, Camacho F, Cooper CL. Erythropoiesis-stimulating agent use for anemia induced by interferon-ribavirin treatment in patients with hepatitis C virus infection is not associated with increased rates of cardiovascular disease, thrombosis, malignancy, or death. Clinical Infectious Diseases 2008; 22(4): 376-380. PMID: 18532889.
Costiniuk CT, Hibbert B, Filion L, Kovacs C, Benko E, O'Brien E and Angel JB. Endothelial Progenitor Cell Levels are Not Reduced in HIV-infected Men. Journal of Infectious Diseases 2012; 205(5): 713-717. PMID: 22238473.
Costiniuk CT, Kovacs K, Routy JP, Singer J, Gurunathan S, Sekaly RP and Angel JB. Human Immunodeficiency Virus Rebound in Blood and Seminal Plasma Following Discontinuation of Antiretroviral Therapy. AIDS Research and Human Retroviruses 2013; 29(2): 266-269. PMID: 22908887.
Chun TW, Shawn Justement J, Murray D, Kim CJ, Blazkova J, Hallahan CW, Benko B, Costiniuk CT, Kandel G, Ostrowski M, Kaul R, Moir S, Casazza JP, Koup RA, Kovacs C, Fauci AS. Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers. Journal of Infectious Diseases 2013; 208(9): 1443-1447. PMID: 23847057.
Costiniuk CT and Jenabian MA. The lungs as HIV reservoirs. Reviews in Medical Virology 2014; 24(1): 35-54. PMID: 24151040.