Keith Murai, PhD - Research Institute of the McGill University Health Centre
brain • plasticity • synapse • disease • development
My research focuses on understanding how the brain encodes information at synapses, the intimate contact points between cells within neural circuits. Work from my research team has provided insight into cellular and molecular pathways that regulate synapses and the contribution of glial cells to brain development and function. The ultimate goal of the research is reveal novel properties of the developing and mature brain and discover potential therapeutic avenues for treating conditions where disregulation of neural circuits occurs.
D. Cook*#, E. Nuro*#, E. V. Jones*, H. F. Altimimi, W. T. Farmer*, V. Gandin, E. Hanna*, R. Zong, A. Barbon, D. L. Nelson, I. Topisirovic, J. Rochford, D. Stellwagen, J-C. Béïque and K. K. Murai (2014). FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation. Cell Reports 9:1402-16.
L. Zhou*, E. V. Jones*, and K. K. Murai (2012). EphA signaling promotes actin-based dendritic spine remodeling through the Slingshot phosphatase. J. of Biological Chemistry, 287:9346-59 PMID: 22282498.
D. Cook, E. Nuro, and K. K. Murai. Increasing our understanding of human cognition through the study of fragile X syndrome (2013). Developmental Neurobiology 74:147-77. PMID: 23723176.
Y. Bernardinelli*, C. Salmon*, E. V. Jones*, W. T. Farmer*, D. Stellwagen, and K. K. Murai (2011). Astrocytes display complex and localized calcium responses to single neuron stimulation in the hippocampus. Journal of Neuroscience, 31:8905-8919. PMID: 21677174.
E. V. Jones*, Y. Bernardinelli*, Y.C. Tse, S. Chierzi*, T. P. Wong, and K. K. Murai (2011). Astrocytes control glutamate receptor levels at developing synapses through SPARC-b-integrin interactions. Journal of Neuroscience, 31:4154-65. PMID: 21411656.