Breadcrumb

null Sampath Loganathan, PhD

Junior Scientist, RI-MUHC, Glen site

Cancer Research Program

Centre for Translational Biology

Assistant Professor, Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

head and neck squamouse cell carcinoma • in vivo CRISPR screens • cancer cell signaling • drug targets

Research Focus

My research focuses on utilizing the in vivo CRISPR methodology to investigate oncological mechanisms that drive the head and neck squamous cell carcinoma (HNSCC) malignancy, with the ultimate goal of developing novel drug targets to treat this deadly cancer.

Selected Publications

Click on Pubmed to see my current publications list

  • Loganathan SK, Schleicher K, Malik A, Quevedo R, Langille E, Teng K, Oh RH, Rathod B, Tsai R, Samavarchi-Tehrani P, Pugh TJ, Gingras AC, Schramek D. Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling. Science. 2020 Mar 13;367(6483):1264-1269. doi: 10.1126/science.aax0902. PMID: 32165588.

  • Loganathan SK, Malik A, Langille E, Luxenburg C, Schramek D. In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity. J Vis Exp. 2020 Nov 2;(165). doi: 10.3791/61693. PMID: 33191932.

  • Loganathan SK, Schneider HP, Morgan PE, Deitmer JW, Casey JR. Functional assessment of SLC4A11, an integral membrane protein mutated in corneal dystrophies. Am J Physiol Cell Physiol. 2016 Nov 1;311(5):C735-C748. doi: 10.1152/ajpcell.00078.2016. Epub 2016 Aug 24. PMID: 27558157.

  • Loganathan SK, Casey JR. Corneal dystrophy-causing SLC4A11 mutants: suitability for folding-correction therapy. Hum Mutat. 2014 Sep;35(9):1082-91. doi: 10.1002/humu.22601. Epub 2014 Jun 28. PMID: 24916015.