ubiquitin • muscle wasting • spermatogenesis • cachexia • diabetes • Parkinson's disease
My research focuses on how degradation of proteins in cells takes place and how this breakdown of proteins in cells is involved in disease. At this time, I am studying the role of such protein breakdown in Parkinson's disease, in sperm development, in the muscle wasting that occurs in illnesses such as cancer, and in metabolic diseases such as obesity and diabetes. Our work may lead to development of drugs to prevent or treat the above disorders.
Bedard N, Yang Y, Gregory M, Cyr DG, Suzuki J, Yu X, Clarke H, Chian RC, Hermo L, O’Flaherty C, Smith CE and Wing SS. Mice Lacking the USP2 Deubiquitinating Enzyme have Severe Male Sub-Fertility Associated with Defects in Fertilization and Sperm Motility. Biol. Repro. 2011, 85: 594-604. PMID: 21543767.
Bilodeau PA, Coyne ES, and Wing SS. The ubiquitin proteasome system in atrophying muscle – roles and regulation. Amer. J. Physiol. Cell Physiol. 2016, 311:C392-403. PMID: 27510905.
Bédard N, Jammoul S, Moore T, Wykes L, Hallauer PL, Hastings KEM, Stretch C, Baracos V, Chevalier S, Plourde M, Coyne E, Wing SS. Inactivation of the USP19 Deubiquitinating Enzyme Protects Against Muscle Wasting. FASEB J 2015, 29:3889-98. doi: 10.1096/fj.15-270579. PMID: 26048142.
Fok KL, Bose R, Sheng K, Chang CW, Katz-Egorov M, Culty M, Su S, Yang M, Ruan YC, Chan HC, Iavarone A, Lasorella A, Cencic R, Pelletier J, Nagano M, Xu W, Wing SS. Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response. Endocrinology. 2017; 158:4000-4016. doi: 10.1210/en.2017-0039. PMID: 28938460.
Coyne ES, Bedard N, Gong YJ, Faraj M, Tchernof A, and Wing SS. The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high fat diet induced obesity and glucose intolerance in mice. Diabetologia, 2019, 62: 136-146. doi: 10.1007/s00125-018-4754-4. PMID: 30386869.