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angle-left Wei-Hsiang Huang, PhD

Junior Scientist, RI-MUHC , Montreal General Hospital

Brain Repair and Integrative Neuroscience (BRaIN) Program

Centre for Translational Biology

Assistant Professor, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University

 

Keywords


autism spectrum disorders • neurodevelopmental disorders • epilepsy • genetic mouse models

Research Focus


My research focuses on understanding how gene dosage imbalance causes human epilepsy. My lab uses genetic mouse models and advanced molecular and neuroscience techniques to dissect how copy number variants affect neural functions on molecular, cellular, circuit, and behavioural levels. We are currently interested in Smith-Magenis syndrome and Potocki-Lupski syndrome, caused by loss and gain of a transcription factor, RAI1. We also study the role of mTOR pathway in hippocampal excitability and neurogenesis.

Selected Publications


Click on Pubmed to see my current publications list

  • Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai EL, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmüller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubenstein JLR, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, Craig AM. Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron. 2020 Feb 5;. doi: 10.1016/j.neuron.2020.01.008. [Epub ahead of print]. PMID: 32027825.

  • Huang WH, Wang DC, Allen WE, Klope M, Hu H, Shamloo M, Luo L. Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith-Magenis syndrome. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10744-10749. doi: 10.1073/pnas.1806796115. Epub 2018 Oct 1. PMID: 30275311.

  • Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HY. Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn. Neuron. 2017 Apr 19;94(2):294-303.e4. doi: 10.1016/j.neuron.2017.03.024. Epub 2017 Apr 6. PMID: 28392070.

  • Huang WH, Guenthner CJ, Xu J, Nguyen T, Schwarz LA, Wilkinson AW, Gozani O, Chang HY, Shamloo M, Luo L. Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Neuron. 2016 Oct 19;92(2):392-406. doi: 10.1016/j.neuron.2016.09.019. Epub 2016 Sep 29. PMID: 27693255.

  • Huang WH, Tupal S, Huang TW, Ward CS, Neul JL, Klisch TJ, Gray PA, Zoghbi HY. Atoh1 governs the migration of postmitotic neurons that shape respiratory effectiveness at birth and chemoresponsiveness in adulthood. Neuron. 2012 Sep 6;75(5):799-809. doi: 10.1016/j.neuron.2012.06.027. PMID: 22958821.